Results 41 to 50 of about 525,629 (353)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Complexation of DNA with Cationic Surfactant
, 1999 Transfection of an anionic polynucleotide through a negatively charged membrane is an important problem in genetic engineering. The direct association of cationic surfactant to DNA decreases the effective negative charge of the nucleic acid, allowing the
Akhtar +30 more
core +2 more sources
Optical evidence for adsorption of charged inverse micelles in a Stern layer [PDF]
, 2020 Understanding the properties and behavior of nonpolar liquids containing surfactant and colloidal particles is essential for applications such as electrophoretic ink displays and liquid toner printing.
Beales, Graham +7 more
core +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Biophysicochemical interaction of a clinical pulmonary surfactant with nano-alumina
, 2015 We report on the interaction of pulmonary surfactant composed of phospholipids and proteins with nanometric alumina (Al2O3) in the context of lung exposure and nanotoxicity.
Berret, J. -F. +3 more
core +4 more sources
The influence of natural pulmonary surfactant on the efficacy of siRNA-loaded dextran nanogels [PDF]
, 2013 Aim: Topical administration of siRNA nanocarriers is a promising approach in the treatment of pulmonary disorders. Pulmonary surfactant, covering the entire alveolar surface of mammalian lungs, will be one of the first interfaces that siRNA nanocarriers ...
Braeckmans, Kevin +4 more
core +1 more source
Chemistry – A European Journal, 2018 AbstractSurfactants are ubiquitous in cellular membranes, detergents or as emulsification agents. Due to their amphiphilic properties, they cannot only mediate between two domains of very different solvent compatibility like water and organic but also show fascinating self‐assembly features resulting in micelles, vesicles, or lyotropic liquid crystals.
Sebastian Polarz +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
MOBILITY REDUCTION OF CO2 USING CO2 SOLUBLE SURFACTANTS [PDF]
, 2012 Addition of slightly CO2-soluble, brine-soluble, surfactants to high pressure CO2 for EOR may facilitate in-situ generation of CO2-in-brine foams for mobility control.
McLendon, William
core
Modelling of surfactant-driven front instabilities in spreading bacterial colonies
, 2018 The spreading of bacterial colonies at solid-air interfaces is determined by the physico-chemical properties of the involved interfaces. The production of surfactant molecules by bacteria is a widespread strategy that allows the colony to efficiently ...
John, Karin +2 more
core +3 more sources