Results 141 to 150 of about 2,292,861 (284)

Periodontitis Induces B Cell‐Macrophage Crosstalk to Exacerbate Glucose Dysregulation in Obesity

Advanced Science, EarlyView.
In obesity, periodontitis exacerbates hyperglycemia and exhibits a liver‐centric preference for glucose regulation. This occurs through a periodontitis‐driven circuit between pathogenic B cells and hepatic macrophages. Their reciprocal expansion, orchestrated by the NLRP3/IL‐18 signaling pathway, amplifies metabolic inflammation and disrupts glucose ...
Wen‐Zhen Lin, Lu‐Jun Zhou, Hui‐Lin Ye, Ting Liu, Bo‐Yan Chen, Xue‐Bing Bai, Jun Zhang, Lan Bai, Lin‐Juan Du, Yuan Liu, Yong‐Li Wang, Hong Zhu, Yu‐Lin Li, Shuo Xu, Xiao‐Qian Meng, Guo‐Cai Tian, Yan Liu, Wu‐Chang Zhang, Ya‐Qin Zhu, Sheng‐Zhong Duan   +19 more
wiley   +1 more source

The Person I Am Becoming

, 2014
Death, among other things, forces us to confront our own mortality, to question how we view ourselves in relation to others, to relive memories be they fond or not so much. Over the past month, I lost both a grandfather -a quiet, intense, intelligent man
Sasala, Ann M.
core  

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Pruritic eruption on the extremities: Report of 2 generations treated with dupilumab

JAAD Case Reports
Anna-Marie Hosking, MD, Lina Saeed, MD, Janellen Smith, MD   +2 more
doaj   +1 more source

Gettysburg Against Gun Violence

, 2018
On April 4th, the 50th Anniversary of the assassination of Dr. Martin Luther King, Jr., Saheed Vassell, a 34 year old black man, was shot nine times and killed in Crown Heights, Brooklyn, NY.
Stewart, Chentese
core  

Chemical Upcycling of Polyphenylene Sulfide at Room Temperature

Advanced Science, EarlyView.
Poly(phenylene sulfide) (PPS) is a semi‐crystalline super engineering plastic with exceptional properties. An iron‐photocatalyzed strategy is reported for chemical upcycling of PPS plastics at room temperature using 1,2‐dichloroethane. The method demonstrates remarkable efficiency across diverse PPS resins and post‐consumer composites, even within ...
Boning Gu, Chengliang Li, Xuefeng Jiang
wiley   +1 more source

Fat People Exist

, 2014
A couple weeks ago, I closed the stall door behind me in a Patrick Hall bathroom and was greeted by this sign. I quickly scanned the text, smiled at the picture, and had one of those warm, fuzzy, faith-in-humanity-has-been-restored kinds of ...
Davin, Julie E.
core  

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo, Ying Yu, Zhimin Zeng, Yanxin Chen, Yali Yi, Zhiqin Lu, Fujuan Zeng, Peng Xu, Daya Luo, Leifeng Chen, Anwen Liu   +10 more
wiley   +1 more source

Evaluation of the Occlusion Break Surge Volume in Five Different Phacoemulsification Systems

Clinical Ophthalmology
Satish Yalamanchili, Ali Aboughaida, Omid S Rohani, David William Dyk Alcon Research LLC, Lake Forest, CA, USACorrespondence: Satish Yalamanchili, Alcon Research LLC, Lake Forest, CA, USA, Tel +1 949 5057261, Email satish.yalamanchili@Alcon.comPurpose ...
Yalamanchili S, Aboughaida A, Rohani OS, Dyk DW   +3 more
doaj  

The Rush to Fit In

, 2018
A week ago, I had been dead set on not rushing. I had heard the rumors and beliefs of my peers, that Greek life encouraged excessive drinking and partying, that hazing was still incredibly prevalent and demeaning, that Greek life worked only to ...
Delaney, Kate M.
core