Results 241 to 250 of about 594,474 (325)

Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Using in vitro DNA damage assays in human T cells, ex vivo profiling of aged immune subsets and a small placebo‐controlled in vivo study, authors show that low‐dose rapamycin, a potent life‐extending mTOR inhibitor, enhances resilience against DNA damage in the human immune system.
Loren Kell   +8 more
wiley   +1 more source

Decreased PTGES2 Farnesylation in Granulosa Cells Compromises PGE2‐Dependent Cumulus Expansion and Oocyte Maturation During Ovarian Aging

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
A schematic showing decreased PTGES2 farnesylation in granulosa cells compromises PGE2‐dependent cumulus expansion and oocyte maturation during ovarian aging. In young ovaries, PTGES2 farnesylation of GCs regulates the process of cumulus expansion and oocyte maturation by facilitating PGE2 production.
Sainan Zhang   +14 more
wiley   +1 more source

Effect of magnetic MMP removal on long‐term dentin collagen stability

open access: yesEuropean Journal of Oral Sciences, Volume 134, Issue 1, February 2026.
Abstract Several matrix metalloproteinase (MMP) inhibitors have been investigated for their ability to improve dentin‐bond longevity. However, MMPs tend to reactivate over time, especially using simplified etch‐and‐rinse adhesives. This study investigated a novel magnetic removal of dentinal MMPs on bonding durability, MMP inhibition and collagen ...
Walter Zenobi   +10 more
wiley   +1 more source

hnRNPU Safeguards Oocyte Development and Female Fertility via Regulation of Alternative Splicing

open access: yesThe FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Heterogeneous nuclear ribonucleoprotein U (hnRNPU) is essential for oocyte development and female fertility. Oocyte‐specific deletion of Hnrnpu leads to follicular arrest, impaired meiotic maturation, mitochondrial dysfunction, and infertility.
Jinmei Li   +8 more
wiley   +1 more source

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