Results 241 to 250 of about 4,416 (303)
Programmed Cell Death in Cancer
Cancer is one of the most common and lethal diseases globally, with programmed cell death (PCD) playing a pivotal role in its pathogenesis and treatment. This comprehensive review covers the origin, developmental trajectory, and mechanisms of various PCDs, as well as their molecular connections with cancers. Latest studies have increasingly highlighted
Yuang Wei+3 more
wiley +1 more source
TGF‐β inhibition is emerging as a promising cancer therapy, yet translating laboratory success to bedside implementation has suffered significant setbacks. The associated challenges include adverse drug reactions, inadequate predictive models, and activation of alternative signaling pathways.
Faizah A. Alabi+5 more
wiley +1 more source
Rare but relevant: Hydrocarbons and sudden sniffing syndrome
Abstract Inhaled hydrocarbon‐associated sudden collapse (IHASC), often referred to as ‘sudden sniffing death syndrome’ is a critical and often fatal event linked to the inhalation of volatile hydrocarbons, primarily occurring in adolescents and young adults. This syndrome manifests as sudden cardiac and/or respiratory arrest, typically occurring during
Ingrid Berling+1 more
wiley +1 more source
Inherited Susceptibility to Cancer: Past, Present and Future
ABSTRACT Germline pathogenic variants (GPVs, ‘mutations’) causing inherited susceptibility to certain cancers (cancer susceptibility genes, CSGs) broadly belong to one of two main classes—loss of function variants in tumour suppressor genes (TSGs) or gain of function variants in proto‐oncogenes (an over‐simplification).
Shirley V. Hodgson+3 more
wiley +1 more source
Determining the life histories of mammals after the extinction of the dinosaurs is key to understanding why they rose so quickly to terrestrial dominance. This study analyses growth in a member of a key mammal group that traversed the extinction boundary.
Gregory F. Funston+3 more
wiley +1 more source
Development of a Low-Energy Mobile Current Waveform Impulse Generator for Application in Low Voltage Surge Arresters [PDF]
Tiago Gonçalves Zacarias+9 more
openalex +1 more source
Abstract This article provides an empirically informed account of the processes for resolving labour disputes in the Philippines. Moving beyond earlier studies that have focused on the ineffectiveness of formal processes, we widen the scope of our inquiry to examine the labour dispute resolution regime as a polycentric regulatory framework. We focus on
CAROLYN SUTHERLAND+1 more
wiley +1 more source
Abstract “Dual pandemics” refers to the combination of COVID‐19 and structural racism in U.S. society—two forces that intersect to exacerbate inequities for marginalized and underrepresented communities. Today, we see marked differences in civic engagement for youth who were adolescents at the onset of the dual pandemics.
Angie Malorni, Sara Wilf
wiley +1 more source
Abstract Prior research has examined individuals' perceptions of punishments (PP) and rewards (PR) for crime, as well as their use of moral disengagement (MD), to understand why adolescents and young adults commit crimes. However, the joint development of these cognitions as a broader risk‐perception mechanism remains understudied.
Romain Decrop+8 more
wiley +1 more source