Results 141 to 150 of about 531,005 (244)

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

From innovation to implementation: Addressing the AI adoption gap in cardiac surgery. [PDF]

Am Heart J Plus
Ngwu D, Hamadi F, Akinyemi O, Wokocha C, Arora N.   +4 more
europepmc   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

Cardiovascular Magnetic Resonance 3D LGE Imaging for Atrial Fibrillation Ablation understanding Left Atrial Structural Changes

Journal of Cardiovascular Magnetic Resonance
Evangelia Nyktari, MD, Sultana Kourtidou, MD, Athanasios Saplaouras, MD, Konstantinos Letsas, MD, PhD, Thomas Vrachliotis, MD, PhD, Panagiotis Rozos, Spyridonas Zarkadoulas, Michaela Schmidt, Karl Kunze, PhD, Michalis Efremidis, MD, PhD   +9 more
doaj   +1 more source

Inactivation Rap2a in Endothelial Cell Prevents Pulmonary Fibrosis by Regulating Immune Microenvironment Through MAP4K4‐VCAM1 Signaling

Advanced Science, EarlyView.
We identified the endothelial RAP2A as a regulator of inflammatory endothelial activation in experimental lung fibrosis and suggest that targeting RAP2A‐mediated signaling may represent a potential strategy to modulate endothelial–immune crosstalk during fibrotic lung injury.
Xiaolan Zheng, Peng Yue, Kaiyu Zhou, Guidong Gong, Yue Zhang, Sha Lin, Xu Liu, Yanjiang Zheng, Siyuan Jing, Junling Guo, Yan Qi, Bi‐Sen Ding, Yimin Hua, Yifei Li   +13 more
wiley   +1 more source

Cardiac Magnetic Resonance-aided Ventricular Tachycardia Substrate Ablation Using a Novel Research Image-navigated Late-gadolinium Enhancement Sequence

Journal of Cardiovascular Magnetic Resonance
Evangelia Nyktari, MD, Sultana Kourtidou, MD, Konstantinos Letsas, MD, PhD, Athanasios Saplaouras, MD, Thomas Vrachliotis, MD, PhD, Spyridonas Zarkadoulas, Panagiotis Rozos, Karl Kunze, PhD, Michaela Schmidt, Michalis Efremidis, MD, PhD   +9 more
doaj   +1 more source

Cardiac Surgery

, 2022
Pingping Song, Michael Holmes, G. Burkhard Mackensen   +2 more
openaire   +1 more source

Astrocytic TIA1‐Mediated Stress Granules Promote the Demyelination of Optic Neuritis by Sequestering mRNA of Cholesterol Synthesis Genes in an Experimental Autoimmune Encephalomyelitis Model

Advanced Science, EarlyView.
Astrocytic TIA1‐mediated stress granules (SGs) promote demyelination by sequestering the mRNA of cholesterol synthesis genes. In this model, astrocytic TIA1‐mediated SGs were increased in the optic nerves of EAE mice, leading to the downregulation of cholesterol synthesis genes such as HMGCS1 through sequestration of their mRNA into SGs, which ...
Zheyu Fang, Xin Hua, Ziwei Fan, Jiaxin Zhao, Yuan Zhang, Qiaoyi Zhang, Xi Qu, Shengli Pan, Bingbing Wan, Shiyin Yang, Jia Li, Xu Zhang   +11 more
wiley   +1 more source

Trackable Tolerogenic Macrophages Integrate PD‐L1 and Rapamycin Signaling to Suppress Alloimmune Responses in Transplantation

Advanced Science, EarlyView.
We developed a macrophage‐based therapeutic platform, termed trackable tolerogenic macrophages (TTM), for dual‐function immunomodulation and visualization in vivo. TTM cells were engineered to overexpress PD‐L1, incorporate bioorthogonal cell surface tags, and load rapamycin for sustained release.
Yihui Wang, Yuan Song, Yuji Xie, Junmin Zhang, Jing Liu, Wenyuan Wang, Ying Xu, Wenqian Wu, Wuqi Zhou, Qiaofeng Jin, Jing Wang, Yali Yang, Li Zhang, Tang Gao, Mingxing Xie   +14 more
wiley   +1 more source

MicroRNAs as Biomarkers of Short-Term Complications After Cardiac Surgery. [PDF]

Genes (Basel)
Kozik A, Kowalewska KK, Piotrowski M, Kowalewski M, Burysz M, Batko J.   +5 more
europepmc   +1 more source