Results 181 to 190 of about 2,672,563 (309)

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

Acute Physiologic and Chronic Health Evaluation II and Simplified Acute Physiology Score 3 Scores as Predictors of Mortality in Cardiac Surgery. [PDF]

Braz J Cardiovasc Surg
Bellettini-Santos T, Frederico RF, Ronchi SN, Silva JL, Pimentel HF, Garcez ML.   +5 more
europepmc   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Life-Saving Emergency Decompression via a Clamshell Approach for Cardiac Arrest Caused by Hemorrhage of a Giant Mediastinal Ectopic Thyroid: A Case Report. [PDF]

Surg Case Rep
Ono M, Watanabe Y, Togo T, Nakano Y, Onodera K, Notsuda H, Kumata S, Takeda T, Ikushima T, Watanabe T, Suzuki T, Hirama T, Oishi H, Okada Y.   +13 more
europepmc   +1 more source

Ultrasound‐Triggered piRNA Delivery Using Biomimetic Phase‐Changeable Nanoparticles for Theranostics of Myocardial Infarction

Advanced Science, EarlyView.
A biomimetic ultrasound‐responsive piRNA delivery nanoparticle platform (piR‐NPs) enables targeted delivery and ultrasound (US)‐triggered release of piR‐1873 in infarcted myocardium. The released piR‐1873 suppresses Usp2‐mediated RIP1/RIP3/MLKL necroptosis, reduces myocardial injury and fibrosis, and promotes cardiac functional recovery, providing a ...
Yajun Zhang, Hongzhao Qi, Yanyan Yang, Feng Wang, Tiantian Han, Yanbei Lei, Xiaolu Li, Zhibin Wang, Hua Qu, Tao Yu, Pin Sun   +10 more
wiley   +1 more source

Cardiovascular Magnetic Resonance 3D LGE Imaging for Atrial Fibrillation Ablation understanding Left Atrial Structural Changes

Journal of Cardiovascular Magnetic Resonance
Evangelia Nyktari, MD, Sultana Kourtidou, MD, Athanasios Saplaouras, MD, Konstantinos Letsas, MD, PhD, Thomas Vrachliotis, MD, PhD, Panagiotis Rozos, Spyridonas Zarkadoulas, Michaela Schmidt, Karl Kunze, PhD, Michalis Efremidis, MD, PhD   +9 more
doaj   +1 more source

RBMS1 Contributes to Early Arteriovenous Fistula Neointimal Remodeling Through Modulation of VSMC Phenotypic Responses

Advanced Science, EarlyView.
Postoperative arteriovenous fistulas exhibit increased RBMS1 in vascular smooth muscle cells (VSMCs). In experimental AVFs, RBMS1 overexpression aggravates, whereas deletion attenuates, neointimal hyperplasia. RBMS1 binds MPZL1 mRNA and promotes exon 5 skipping to generate MPZL1‐Δ5, which interacts with G3BP1 to activate AKT, driving VSMC proliferation,
Zongda Li, Chengwei Zhang, Xinying Yu, Shuang Yao, Yiting Lai, Xiaozhu Sun, Yao Zhao, Xiaoyu Lan, Tingting Hu, Wenjin Li, Zhenzhen Ma, Huimin Ma, Zihan Wang, Haihai Liang, Jundong Jiao   +14 more
wiley   +1 more source

The dynamic adrenal response of children to cardiac surgery and cardiac catheterization.

J Clin Endocrinol Metab
Fudulu DP, Marinelli I, Galvis D, Zavala E, Walker-Smith T, Evans J, Papadopoulou F, Upton T, Ramesh A, Rapetto F, Kershaw Y, Fox J, Aramburo A, Stoica SC, Caputo M, Parry A, Macrae D, Michielon G, Hoschtitzky JA, Sheehan K, van Faassen M, Kema I, Angelini GD, Lightman S, Gibbison B.   +24 more
europepmc   +1 more source

Extending the Lower Limits of Body Weight for Bi-directional Glenn Shunt in Developing Countries: Is it Feasible? [PDF]

Cureus
Talwar S, Das D, Bhende VV, Gohil AA, Krishnakumar M, Sharma AS.   +5 more
europepmc   +1 more source