Results 191 to 200 of about 2,672,563 (309)

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao, Long He, Yu Lu, Zanglong Deng, Hongzhen Wei, Yunpeng Zhang, Ming Yang, Tao Yin   +7 more
wiley   +1 more source

Cardiac Magnetic Resonance-aided Ventricular Tachycardia Substrate Ablation Using a Novel Research Image-navigated Late-gadolinium Enhancement Sequence

Journal of Cardiovascular Magnetic Resonance
Evangelia Nyktari, MD, Sultana Kourtidou, MD, Konstantinos Letsas, MD, PhD, Athanasios Saplaouras, MD, Thomas Vrachliotis, MD, PhD, Spyridonas Zarkadoulas, Panagiotis Rozos, Karl Kunze, PhD, Michaela Schmidt, Michalis Efremidis, MD, PhD   +9 more
doaj   +1 more source

Changes in skeletal muscle and physical function after cardiac surgery: a prospective study. [PDF]

J Nutr Health Aging
Svidt P, Daugaard R, Lading T, Modrau IS.   +3 more
europepmc   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Effects of Adding Incentive Spirometry to Hospital-Based Cardiovascular Rehabilitation on Pulmonary Complications, Hospital Length of Stay, and Clinical-Functional Recovery After Cardiac Surgery: A Randomized Controlled Trial. [PDF]

Physiother Res Int
Messias BEDS, Silva TASD, Schreiner RA, Torres L, Bischoff J, Oliveira TF, Peringer V, Bortagarai FM, Marques MD, Eibel B, Callegaro CC.   +10 more
europepmc   +1 more source

Tubocapsenolide A Overcomes Oxaliplatin Resistance in Colorectal Cancer by Targeting PLK1 to Impair CEP55–ESCRT‐Associated Vesicular Damage Clearance

Advanced Science, EarlyView.
Oxaliplatin‐resistant colorectal cancer cells utilize a previously unappreciated PLK1‐CEP55‐ESCRT‐driven vesicular extrusion mechanism to clear L‐OHP‐induced cellular damage. The natural withanolide Tubocapsenolide A directly targets and inhibits PLK1 to disrupt this specific damage‐clearance machinery. This blockade induces severe nucleolar stress and
Yueying Yang, Jing Liang, Lu Wang, Hongyan Zhang, Zhiruo Zhang, Yang Liu, Rui Zhu, Wen Xu, Shaohua Xu, Dejuan Sun, Ke Xiang, Yali Wang, Zhimin Fan, Zheng Wang, Hua Li, Lixia Chen   +15 more
wiley   +1 more source

Incidence and risk factors for delirium in cardiac surgery intensive care unit patients: A single-center study. [PDF]

World J Crit Care Med
Dimitriadis F, Kourek C, Rouvali N, Kinti C, Mavraki M, Georgopoulou M, Pitsolis T, Maragkoulia T, Kolovou K, Konstantinou G, Soulele T, Zervos M, Salata P, Elaiopoulos D, Doubou D, Panagiotou C, Dimopoulos S.   +16 more
europepmc   +1 more source

Symptom‐Driven Prediction of Chronic Multimorbidity with a Macro–Micro Heterogeneous Graph Neural Network

Advanced Science, EarlyView.
Clinical symptoms offer a window into multimorbidity. A macro‐micro heterogeneous graph neural network integrates clinical records with biomedical knowledge to improve patient‐level symptom‐disease association learning and visit‐level multimorbidity completion.
Yiheng Ye, Miaoru Han, Siqiao Tang, Zongxiang Zhang, Haichen Shen, Bingzhen Sun, Yan Zhang, Xiaodong Chu, Lijuan Deng, Chaoyang Zheng, Qingchun Huang, Kun Bao, Ronghua Zhang, Yong Wang, Fengwei Zhang, Xiaoli Chu   +15 more
wiley   +1 more source

Preoperative Carriage of Respiratory Viruses and Acute Respiratory Distress Syndrome After Cardiac Surgery: Protocol for the VIRUS-ATTAC Prospective Cohort Study. [PDF]

JMIR Res Protoc
Nesseler N, Bouglé A, Rozec B, Mongardon N, Kerforne T, Rousseau C, Flécher E, Verhoye JP, Beaudeau M, Ross JT, Gervais ML, Fougerou-Leurent C, Tattevin P, Thibault V, Pilon C, Pronier C, Mansour A.   +16 more
europepmc   +1 more source

Macrophage GLUD1 is Essential for Redox Balance and Immune Homeostasis in Cardiac Injury

Advanced Science, EarlyView.
Excessive free radical production and dysregulated immune responses are key contributors to myocardial ischemia‐reperfusion (IR) injury. Macrophage GLUD1 activity safeguards against HIF‐1α accumulation and maladaptive responses to IR‐induced ROS production.
Tingting Jin, Chaojie Lai, Qingyan Zhou, Ruilin Wang, Yiping Tong, Wentao Chen, Nikola Rabrenovic, Tingyu Zhang, Xinrong Ren, Chengchen Huang, Jiawen Chen, Ran Li, Luyang Yu, Massimiliano Mazzone, Wenbin Zhang, Guosheng Fu, Min Shang   +16 more
wiley   +1 more source