Results 71 to 80 of about 4,600,529 (346)

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

Assessing the Safety of Combined Therapy, Croton membranaceus and Tamsulosin, in the Self-Prescribed Treatment Protocol for Benign Prostatic Hyperplasia

Journal of Toxicology
Conclusion: The results suggest that the combination of C. membranaceus and tamsulosin does not provide additional therapeutic benefits for treating BPH. Relative organ weights provide a better evaluation metric than total organ weights.
Cosmos Gborsong, George A. Asare, Robert A. Ngala, Christian Obirikorang, Josephine Ablakwa, Bernice Asiedu, Samuel Adjei, Osei Afriyie, Daniel Afriyie, Mokbul Hossain, Munmun Pervin, Md. Mahmudul Alam, Mst. Antora Akter, Mohammed Habibur Rahman   +13 more
doaj   +1 more source

Costs of surgeries in low- and middle-income countries: a systematic literature review

BMJ Global Health
Background Surgical care is essential for achieving global health equity, yet low- and middle-income countries (LMICs) face major gaps in access and planning, partly due to limited evidence on the costs and resource requirements of surgical interventions.
Rocco Friebel, Rachel Hargest, Soham Bandyopadhyay, Martilord Ifeanyichi, Danyal Zaman Khan, Phyllis Tenkorang, Meskerem Aleka Kebede, Maeve Bognini, George Duke Mukoro, Esther Matey, Chizowa Okwuchukwu Ezeaku, Oluwayemisi Ekor, Jose Luis Mosso-Lara, Pedra Rabiee   +13 more
doaj   +1 more source

Maternal and obstetric complications in fetal surgery for prenatal myelomeningocele repair: a systematic review.

Neurosurgical Focus, 2019
OBJECTIVE Comparing prenatal and postnatal surgical repair techniques for myelomeningocele (MMC), in utero fetal surgery has increasingly gained acceptance and is considered by many specialized centers the first choice of treatment. Despite its benefits,
M. Licci, R. Guzman, J. Soleman
semanticscholar   +1 more source

Real‐Time in Vivo Monitoring of Circulating Endometrial Cells: Uncovering Systemic Dissemination and Temporal Fluctuations in Endometriosis

Advanced Science, EarlyView.
A dual‐color pseudo‐menstrual mouse model enables real‐time tracing of circulating endometrial cells (CECs) from uterine and ectopic sources. The study reveals menstrual‐phase‐dependent, burst‐like CEC release, distinct postoperative behaviors of different CEC origins, and a potential association with prolactin fluctuations, providing an in vivo ...
Shang Wang, Chenyu Hou, Buyun Li, Hongyan Cheng, Xue Ye, Honglan Zhu, Yanmin Li, Rui Chen, Sihan Dong, Yi Li, Huiping Liu, Chen Zhang, Rui Zhang, Hongyi Hou, Xunbin Wei, Xiaohong Chang   +15 more
wiley   +1 more source

Emergency Non–obstetric Abdominal Surgery in Pregnancy. [PDF]

, 2008
Background: Despite recent advances in anaesthetic, perinatal and preoperative care, surgical intervention during pregnancy may still result in fetal loss from either spontaneous abortion (especially in the first trimester) or premature labor (especially
Akinola, D.O., Agbakwuru, E.A., Ogunniyi, S.O., Alatise, O.I., Lawal, O.O., Faponle, A.F., Adesunkanmi, A.R.K., Dare, F.O.   +7 more
core   +2 more sources

Interfascial Plane Blocks in Obstetric and Gynecologic Surgery

Acta Clinica Croatica, 2022
Introduction: Interfascial plane blocks (IPB) are truncal blocks with local anesthetic injected into space between two muscle layers. IPBs are easy to learn, simple to perform, provide satisfactory analgesia up to 24 hours, having a minimal risk of ...
Nada Pejčić, Radomir Mitić, Neeti Sadana, Ivan Veličković   +3 more
doaj   +1 more source

Paternal Sperm Gnas‐ICR Epigenetic Programming Contributes to PPP‐Like Phenotypes in Female Offspring

Advanced Science, EarlyView.
A paternal glucocorticoid–sperm Gnas‐ICR axis is linked to ovarian endocrine programming in female offspring. Paternal preconception caffeine exposure elevates corticosterone, promotes sperm Gnas‐ICR hypermethylation, and is associated with ovarian Gnas upregulation, cAMP/PKA/CREB–StAR activation, enhanced estradiol synthesis, and PPP‐like phenotypes ...
Jing Huang, Lu Chen, Tiancheng Wu, Yating Li, Hui Wang   +4 more
wiley   +1 more source

Repair failure and associated factors among women who underwent obstetric fistula surgery in Southwest Ethiopia: A retrospective study

Women's Health, 2023
Background: Surgical repair is one of the management strategies for obstetric fistulae, which are associated with tragic obstetric morbidities. Objective: This study assessed the proportion of repair failures and associated factors among women who ...
Wubishet Gezimu, Tadesse Sime, Aboma Diriba, Diriba Gemechu   +3 more
doaj   +1 more source

Emergency non–obstetric abdominal surgery in pregnancy [PDF]

, 2016
Background: Despite recent advances in anaesthetic, perinatal and preoperative care, surgical intervention during pregnancy may still result in fetal loss from either spontaneous abortion (especially in the first trimester) or premature labor (especially
Lawal, OO, Akinola, DO, Dare, FO, Ogunniyi, SO, Alatise, OI, Faponle, AF, Agbakwuru, EA, Adesunkanmi, ARK   +7 more
core   +1 more source