Results 81 to 90 of about 592,753 (266)

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Submandibular Gland Invasion From a Metastatic Lymph Node in Patients With Buccal Mucosal Squamous Cell Carcinoma: A Case Report

Case Reports in Dentistry
This report presents a rare case of direct invasion from a metastatic submandibular lymph node (SMLN) to submandibular gland (SMG) in a resected specimen of neck dissection (ND) of buccal mucosal squamous cell carcinoma (SCC).
Moeka Bukawa, Kenji Yamagata, Satoshi Fukuzawa, Shohei Takaoka, Fumihiko Uchida, Naomi Ishibashi-Kanno, Hiroki Bukawa   +6 more
doaj   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Spontaneous Exposure of Mandibular Torus: A Case Report and Surgical Management

Case Reports in Dentistry
Conclusion: The patient recovered without complications, and no recurrence of symptoms was noted during the 1-year follow-up. This case highlights the need for prompt surgical intervention in cases of spontaneous torus exposure and the importance of ...
Priscilla Sergi, Subhi Tayeb, Carlo Barausse, Gerardo Pellegrino, Lorenzo Roccoli, Stefano Ratti, Pietro Felice   +6 more
doaj   +1 more source

A French practice study within the Group for the Study of Oral Mucosa (GEMUB): Allopathic treatment of oral lichen

Journal of Oral Medicine and Oral Surgery
Lichen planus is a chronic inflammatory dermatosis of unknown origin, generally affecting the skin, nails and scalp. It can also affect the mucous membranes of the oral cavity and ano-genital region. Due to the paucity of randomised controlled trials, no
Ménager Lélia, Galvez Paul, Catros Sylvain, Fénélon Mathilde, Fricain Jean-Christophe   +4 more
doaj   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Keratocystoma of palatal minor salivary glands: a case report

Journal of Oral Medicine and Oral Surgery
Keratocystoma is a rare benign tumor of the salivary glands. Initially described as a choristoma by Seifert et al. in 1999, the term “keratocystoma” was later proposed by Nagao et al. in 2001. The parotid gland is the most common site of occurrence. Only
Benaouf Souad, Kraloua Saadia, Larbi Meriem, El Amine Khebichat Moncef, Tabeti-Bentahar Cherifa Faiza   +4 more
doaj   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Recurrent Ameloblastoma of the Mandibular Ramus Resected Using a Modified High Perimandibular Approach: A Case Report

Case Reports in Dentistry
Ameloblastoma typically lacks a well-defined capsule and exhibits locally invasive growth, making them prone to recurrence. On the other hand, a subtype known as the unicystic type is generally well circumscribed and less invasive compared with ...
Atsushi Uesugi, Kumiko Kamada, Keiko Kudoh, Naito Kurio   +3 more
doaj   +1 more source