Results 61 to 70 of about 262,309 (263)

Oxygen Vacancy‐Enriched Platinum Single‐Atom Nanozyme Wrapped in Nanoislands: Unlocking Catalytic Activity and Reprogramming Redox Microenvironment for Osteonecrosis Repair

Advanced Science, EarlyView.
CeO2‐x/Pt single‐atom nano‐island is constructed via low‐temperature reduction, featuring abundant oxygen vacancies and an island–sea structure. It delivers outstanding multi‐enzyme‐mimetic activity and ROS‐scavenging efficiency. Density functional theory reveals optimized electronic structures and reaction pathways.
Yang Zhu, Zehui Lv, Xuejie Cai, Penghui Wei, Dengliang Wang, Zhao Wang, Ruoying Wang, Yingjie Wang, Xingdong Yang, Yixin Bian, Jiawei Xu, Xisheng Weng, Liangfeng Wei   +12 more
wiley   +1 more source

ORTHOPEDIC SURGERY IN THE AGING POPULATION: CHALLENGES AND FUTURE DIRECTIONS

Tạp chí Sức khỏe và Lão hóa (Journal of Health and Aging)
The rapid aging of the global population has led to a substantial rise in the demand for orthopedic surgery among elderly patients, particularly for hip, knee, and shoulder arthroplasty.
Tran Quoc Doanh, Ho Bui Dieu Linh, Tran Khoi Luan, Vu Quoc Hung, Nguyen Van Binh, Tran Duc Tai, Dang Thi Hai An, Doan Van Khue, Le My Huyen, Nguyen Anh Sang   +9 more
doaj   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Treatment of complex regional pain syndrome using free-flap surgery: a case report

Journal of Pain Research, 2017
Dong-Kyo Seo,1 Ho-Seong Lee,2 Joon Pio Hong,3 Jeong-Ho Seo,4 Jin Woo Shin5 1Department of Orthopedic Surgery, GangNeung Asan Hospital, College of Medicine, University of Ulsan, GangNeung-si, South Korea; 2Department of Orthopedic Surgery, 3Department of ...
Seo DK, Lee HS, Hong JP, Seo JH, Shin JW
doaj  

Osteopathic Student Matriculation Trends in Surgical Subspecialties (2016-2024): A Systematic Review

Journal of Medical Education and Curricular Development
Background There is a paucity of data on trends of osteopathic medical students (OMS) matriculating into surgical specialties since the installation of the single U.S.
Bridgette Kielhack, Selena K. Cholak, Virgil K. DeMario, Vaishnavi J. Patel, Devki Patel, Kimberly Toumazos, Mark Quiring, Young Son, John Etlinger   +8 more
doaj   +1 more source

PROGRESS IN ORTHOPEDIC SURGERY [PDF]

Archives of Surgery, 1921
TUBERCULOSIS Treatment of Paraplegia in Pott's Disease by Puncture of Spinal Abscess.—Calve1believes that paraplegias are less likely to recover under nonoperative treatment in adults than in children. He reminds us that they occur almost exclusively in those cases in which the lesion is located in the dorsal vertebrae, and he thinks the common cause ...
openaire   +2 more sources

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Factors influencing the selection criteria of Saudi board orthopedic surgery applicants: a national survey of program directors

BMC Medical Education
Background Annually, medical students vie to secure a seat with an orthopedic residency program. This rigorous competition places orthopedic surgery as one of the most competitive specialties in the medical field.
Suhail S. AlAssiri, Alwaleed A. Alshahir, Sami I. Al Eissa, Fahad H. Al Helal, Faisal M Konbaz, Majed S. Abaalkhail, Rayed M. Al Jehani, Abdullah F. Mohabbat, Khalid A. AlSheikh   +8 more
doaj   +1 more source

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Advanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang   +14 more
wiley   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source