Results 21 to 30 of about 266,207 (265)

Customizable and Cost-effective Template for Fibular Osteotomies in Mandibular Reconstruction

Plastic and Reconstructive Surgery, Global Open
Summary:. The free fibula flap is the gold standard for mandibular reconstruction in head and neck tumors. Traditionally, a titanium reconstruction plate is shaped to measure and align with the mandibular defect after ensuring proper occlusion.
Nida Sehar, MBBS, Fizzah Arif, MBBS, Safdar Ali Shaikh, MBBS, FCPS (Plastic Surgery)   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Pilot Study: Innovative Minimally Invasive Tarsal Tunnel Release for Diabetic Foot Ulcer Patients Minimizing Drawbacks

Plastic and Reconstructive Surgery, Global Open
Background:. Diabetic foot ulcers are challenging to manage due to the multifactorial nature of the disease, with diabetic neuropathy being a primary contributing factor.
Hian Kim Erica Ngiam, MBBS, MRCS, Wenxian Png, MBBS, MMed (Ortho), MRCSEd, FRCSEd (Ortho), Eric Wei Liang Cher, MD, MRCS, MMed (Ortho), FRCSEd (Ortho), Jack Kian Ch’ng, MBBS, MRCS, FRCS, Allen Wei Jiat Wong, MBBS, MRCS, MMed, FAMS (Plastic Surgery), Yee Onn Kok, MBBS, MRCS, MMed, FAMS (Plastic Surgery), Jiajun Feng, MD, MRCS, MMED (Surgery), FAMS (Plastic Surgery)   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Consensus of Chinese Experts on Neck Injection Aesthetics (2024 Edition)

Xiehe Yixue Zazhi
Neck injection aesthetic, a commonly performed clinical procedure, is still lacking in comprehensive guidelines or consensus. This expert consensus is co-authored by experts from the Injection Aesthetics of the National Quality Control Center of Plastic ...
Professional Panel on Injection Aesthetics, National Quality Control Center for Plastic and Aesthetic Surgery
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Small Bowel Obstruction Conservatively Managed in Hospital-At-Home

Case Reports in Gastrointestinal Medicine, 2022
In 2020, Mayo Clinic established an Advanced Care at Home (ACH) program. ACH is a virtual hybrid hospital-at-home (HaH) program that combines telemedicine with in-home care services by utilizing a state that is software-driven, vendor-mediate medical ...
Margaret R. Paulson, Abdullah S. Eldaly, Francisco R. Avila, Ricardo A. Torres-Guzman, Karla C. Maita, John P. Garcia, Luiza Palmieri Serrano, Omar S. Emam, Antonio J. Forte, Michael J. Maniaci   +9 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Light‐Assisted 3D Printing Techniques and Photocrosslinking Strategies: Recent Advances in Musculoskeletal Tissue Engineering

Advanced Engineering Materials, EarlyView.
In this review, the current state of light‐assisted 3D printing as it pertains to engineering musculoskeletal tissues including bone, cartilage, skeletal muscle, tendon, and ligaments is summarized. Common printing techniques, photoreactive materials, and study design choices are compiled and reviewed.
Meagan Morgan, Bin Zhang, Roger Narayan
wiley   +1 more source