Results 101 to 110 of about 6,007,559 (305)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Abdominal cocoon: A case report
The Annals of African Surgery, 2009 An abdominal cocoon is an uncommon condition in which there is a total or partial encapsulation of the small bowel by fibrous membrane. A preoperative diagnosis is seldom made.
D. Ojuka, MBChB, MMed, Surgery +1 more
doaj
Arthroscopy, Sports Medicine, and RehabilitationPurpose: To report the proportion of patients who have long-enough hamstring (HS) tendons to prepare an anterior cruciate ligament reconstruction (ACLR) graft of 5 strands, 6 strands, 7 strands, or 8 strands in patients with a small 4-strand HS ACLR ...
W.P. Yau, M.B.B.S., F.R.C.S.Ed., F.H.K.C.O.S., F.H.K.A.M. (Orthopaedic Surgery)
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
Pediatric Burns at The Rift Valley Provincial General Hospital, Nakuru, Kenya
The Annals of African Surgery, 2010 Aim: To determine the etiology and outcome of pediatric burns (0-12 years). Design: A retrospective study of burn victims hospitalized at the Rift Valley Provincial General Hospital, Nakuru, Kenya from April 2004 to March 2007 Method: Charts of all
Oduor P.R., MBChB, MMed, Department of Surgery
doaj
Cervical Deformity Patients Have Baseline Swallowing Dysfunction but Surgery Does Not Increase Dysphagia at 3 Months: Results From a Prospective Cohort Study. [PDF]
, 2019 Study designProspective cohort study.ObjectivesMost studies of dysphagia in the cervical spine have focused on a degenerative patient population; the rate of dysphagia following surgery for cervical deformity (CD) is unknown.
Ames, Christopher P +11 more
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