Results 91 to 100 of about 6,007,559 (305)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Obstructing finite surgery [PDF]

open access: yes, 2013
For a fixed p, there are only finitely many elliptic 3-manifolds given by p/q-surgery on a knot in S^3. We prove this result by using the Heegaard Floer correction terms (d-invariants) to obstruct elliptic manifolds from arising as knot surgery.Comment ...
Doig, Margaret I.
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Aneurysmal Veins in Free Flaps: A Rare Case Report and Discussion

open access: yesPlastic and Reconstructive Surgery, Global Open
Summary:. Microvascular anastomosis is a fundamental technique in reconstructive surgery, where careful selection and meticulous handling of vessels are critical in preventing thrombosis—the leading cause of flap failure. Despite the extensive literature
Manisha Anbudurai, MBBS   +9 more
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1392-1397, June 2026.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

“Yes! I Had Cosmetic Surgery”: Celebrities\u27 Comsmetic Surgery Confessions in the Media and Their Impact on Korean Female College Students\u27 Perceptions. [PDF]

open access: yes, 2012
This paper analyzes celebrities’ cosmetic surgery confessions in the media and explores the impact of the confessions on non-celebrities. Based on the analysis of talk shows and online news in Korea today, I argue that celebrities’ confessions are the ...
Chae, Jiyoung
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Physical therapy management, surgical treatment, and patient-reported outcomes measures in a prospective observational cohort of patients with neurogenic thoracic outlet syndrome [PDF]

open access: yes, 2019
OBJECTIVE: To assess the results of physical therapy management and surgical treatment in a prospective observational cohort of patients with neurogenic thoracic outlet syndrome (NTOS) using patient-reported outcomes measures. METHODS: Of 183 new patient
Abuirqeba, Ahmmad A   +7 more
core   +1 more source

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