Results 151 to 160 of about 6,742,024 (351)

Transcatheter versus surgical aortic-valve replacement in high-risk patients.

New England Journal of Medicine, 2011
Craig R. Smith, M. Leon, M. Mack, D. C. Miller, J. Moses, L. Svensson, E. Tuzcu, J. Webb, G. Fontana, R. Makkar, M. William, T. Dewey, S. Kapadia, V. Babaliaros, V. Thourani, P. Corso, A. Pichard, J. Bavaria, H. Herrmann, J. Akin, W. Anderson, Duolao Wang, S. Pocock   +22 more
semanticscholar   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study.

Journal of the National Cancer Institute, 1999
B. Fisher, J. Costantino, D. Wickerham, C. Redmond, M. Kavanah, W. Cronin, V. Vogel, A. Robidoux, N. Dimitrov, J. Atkins, M. Daly, S. Wieand, E. Tan-chiu, L. Ford, N. Wolmark   +14 more
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Surgical Safety Checklist to Reduce Morbidity and Mortality in a Global Population

New England Journal of Medicine, 2009
Alex B. Haynes, T. Weiser, William R. Berry, Stuart R. Lipsitz, A. Breizat, E. Dellinger, T. Herbosa, S. Joseph, P. Kibatala, M. C. Lapitan, Alan Merry, K. Moorthy, Richard K. Reznick, Bryce R. Taylor, A. Gawande   +14 more
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017

JAMA Surgery, 2017
S. Berríos-Torres, C. Umscheid, D. Bratzler, B. Leas, E. Stone, R. Kelz, C. Reinke, S. Morgan, J. Solomkin, J. Mazuski, E. Dellinger, Kamal M. F. Itani, E. Berbari, J. Segreti, J. Parvizi, Joan C. Blanchard, G. Allen, J. Kluytmans, R. Donlan, W. Schecter   +19 more
semanticscholar   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Surgical or Transcatheter Aortic‐Valve Replacement in Intermediate‐Risk Patients

New England Journal of Medicine, 2017
M. Reardon, N. Van Mieghem, J. Popma, N. Kleiman, L. Søndergaard, M. Mumtaz, David H. Adams, G. Deeb, Brijeshwar Maini, H. Gada, S. Chetcuti, T. Gleason, J. Heiser, R. Lange, William M. Merhi, Jae K. Oh, P. Olsen, N. Piazza, Mathew R. Williams, S. Windecker, S. Yakubov, E. Grube, R. Makkar, Joon S. Lee, J. Conte, E. Vang, H. Nguyen, Yanping Chang, Andrew S. Mugglin, P. Serruys, A. Kappetein   +30 more
semanticscholar   +1 more source