Results 161 to 170 of about 2,802,688 (299)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Surgical Margin Reduction After Immunotargeted Neoadjuvant Therapy in Locally Advanced Hypopharyngeal Carcinoma: A Preliminary Margin Results from neoCHANCE-1 Trial. [PDF]

J Otolaryngol Head Neck Surg
Wang D, Wei J, Jiang Z, Wei Z, Ainiwaer M, Zhao P, Fan L, Wang L, Li L, Lei D, Chen F, Chen H, Peng X, Liu J.   +13 more
europepmc   +1 more source

Towards a full capacity of anaesthesia and surgical services in the epicenter (Wuhan) of the COVID-19 epidemic [PDF]

, 2020
Jun Wu, Shuang Yao, Renyu Liu
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Beyond the Knife: Evolution, Innovation, Challenges, Global Gaps, and the Future of Acute Care Surgery. [PDF]

Cureus
Badero OJ, Omokore O, Quadri IO, Ogunnoiki SO, Kingdom P, Ifeanyichukwu OC, Olayinka T, Samuel-Ogunnoiki PM, Meribole ES, Adeyoola OO, Chima-Ogbuiyi N, Osibowale B, Buari MO, Umeh J.   +13 more
europepmc   +1 more source

Replacement of surgical vasectomy through the use of wild-type sterile hybrids

, 2021
Chris Preece, Samy Alghadban, Amine Bouchareb, Daniela Moralli, Daniel Biggs, Benjamin Davies   +5 more
openalex   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Surgical Residents' Feedback Perceptions: A Scoping Review on Gaps and Improvements. [PDF]

Clin Teach
Costa CDDS, Silva GG, Santos ERD, Lima ARA, Brienze VMS, Oliani DCMV, Oliani AH, André JC.   +7 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

A rare surgical emergency during pregnancy: a case report. [PDF]

J Surg Case Rep
Ibrahim Z, Zakaria G, Amina AB, Boufeloussen M, Yahia K, Hassan AF.   +5 more
europepmc   +1 more source