Results 81 to 90 of about 4,761,266 (345)

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Efeitos da bromoprida na cicatrização de anastomoses no cólon esquerdo de ratos

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Avaliar os efeitos da bromoprida sobre a formação de aderências e a cicatrização de anastomoses de cólon esquerdo de ratos. MÉTODOS: Foram incluídos 40 ratos, divididos em dois grupos contendo 20 animais, para administração de bromoprida (grupo
Silvana Marques e Silva, Vânia Maria Moraes Ferreira, Fabiana Pirani Carneiro, Omar Feres, Paulo Gonçalves de Oliveira, João Batista de Sousa   +5 more
doaj   +1 more source

Surgical approach to hysterectomy for benign gynaecological disease.

Cochrane Database of Systematic Reviews, 2015
BACKGROUND The four approaches to hysterectomy for benign disease are abdominal hysterectomy (AH), vaginal hysterectomy (VH), laparoscopic hysterectomy (LH) and robotic-assisted hysterectomy (RH).
J. Aarts, T. Nieboer, N. Johnson, E. Tavender, R. Garry, B. Mol, K. Kluivers   +6 more
semanticscholar   +1 more source

Surgical innovation [PDF]

British Journal of Surgery, 2015
More necessary than ...
Chc Dejong, J.J. Earnshaw
openaire   +3 more sources

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Two-year outcomes after transcatheter or surgical aortic-valve replacement.

New England Journal of Medicine, 2012
BACKGROUND The Placement of Aortic Transcatheter Valves (PARTNER) trial showed that among high-risk patients with aortic stenosis, the 1-year survival rates are similar with transcatheter aortic-valve replacement (TAVR) and surgical replacement. However,
S. Kodali, Mathew R. Williams, Craig R. Smith, L. Svensson, J. Webb, R. Makkar, G. Fontana, T. Dewey, V. Thourani, A. Pichard, M. Fischbein, W. Szeto, Scott Lim, K. Greason, P. Teirstein, S. Malaisrie, P. Douglas, R. Hahn, B. Whisenant, A. Zajarías, Duolao Wang, J. Akin, W. Anderson, M. Leon, T. Investigators   +24 more
semanticscholar   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Antibiotics in surgical wards: use or misuse? A newly industrialized country’s perspective

Journal of Infection in Developing Countries, 2015
Introduction: Studies exploring the appropriateness of therapeutic antibiotic use among surgical patients are limited, particularly in developing countries. Therefore, the aim of our study was to determine the appropriateness of antibiotics prescribed in
Mun Kit Lim, Pauline Siew Mei Lai, Sasheela Sri La Sri Ponnampalavanar, Sharifah Faridah Syed Omar, Nur Aishah Taib, Mohamad Yasim Yusof, Claire Marie Italiano, David Chee Ming Kong, Adeeba Kamarulzaman   +8 more
doaj   +1 more source