Results 51 to 60 of about 1,971,309 (276)

Non-linear finite element analyses of the aortic heart valve [PDF]

, 2004
Includes bibliographical references.Finite element models of the aortic heart valve have been successfully used in the past to gain insight into the mechanics of the valve and to aid in understanding of valve failure.
Koch, Thorsten M
core   +1 more source

#4 Surgical Outcomes and Decision Making for Bicuspid Aortic Valve

Graduate Medical Education Research Journal
Mentor: Angela Yetman Program: Pediatrics – Cardiology Type: Original Research Background: Bicuspid aortic valve (BAV) is the most common congenital heart lesion and is associated with aortic stenosis or regurgitation, endocarditis, and/or ascending ...
Adam Larsen, David Danford, Angela Yetman   +2 more
doaj   +1 more source

Case report: Self-expanding transcatheter valve implantation (Acurate Neo 2) in a very small native aortic annulus

Frontiers in Cardiovascular Medicine, 2023
Transcatheter aortic valve replacement (TAVR) is a treatment of choice in patients with symptomatic severe aortic valve stenosis (AS) and intermediate-to-high surgical risk.
Massimo Medda, Francesco Casilli, Marta Bande, Maurizio Tespili, Francesco Donatelli   +4 more
doaj   +1 more source

Reoperative Surgical Aortic Valve Replacement Versus Transcatheter Valve-in-Valve Replacement for Degenerated Bioprosthetic Aortic Valves [PDF]

The Annals of Thoracic Surgery, 2016
Bioprosthetic aortic valve use has increased steadily according to The Society of Thoracic Surgeons (STS) database analyses. One of the momentums toward this trend is the future utilization of transcatheter valve-in-valve (TViV) techniques when bioprosthetic valves fail.
Julius I, Ejiofor, Maroun, Yammine, Morgan T, Harloff, Siobhan, McGurk, Jochen D, Muehlschlegel, Prem S, Shekar, Lawrence H, Cohn, Pinak, Shah, Tsuyoshi, Kaneko   +8 more
openaire   +2 more sources

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Transcatheter Aortic Valve Replacement versus Surgical Aortic Valve Replacement: A Review of Aortic Stenosis Management [PDF]

Cureus, 2019
Severe aortic stenosis (AS) affects 3.4% of the elderly over 60 years of age. It presents with exertional dyspnea, syncope, angina, and progression to irreversible congestive heart failure. Early intervention produces a better outcome in preventing the clinical deterioration of AS.
Sattar, Yasar, Rauf, Hiba, Bareeqa, Syeda Beenish, Ullah, Waqas, Myla, Madhura   +4 more
openaire   +2 more sources

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Perioperative Outcomes After Bioprosthetic Valve Replacement in Patients Sensitized to Alpha-Gal

Annals of Thoracic Surgery Short Reports
Background: Alpha-gal syndrome from tick bites, due to sensitivity to alpha-gal, can cause severe allergies. Heart valve implants contain alpha-gal, yet alpha-gal syndrome screening is not standard before valve replacement.
Berk Aykut, MD, Hoe King Lim, BEng, Smith M. Ngeve, BA, Anna Hoover, BS, Cathlyn K. Medina, BA, Jacob Scherba, BS, Ashley Menken, BS, Douglas M. Overbey, MD, MPH, Tariq M. Omer, MS, Scott P. Commins, MD, PhD, Joseph R. Nellis, MD, MBA, Joseph W. Turek, MD, PhD   +11 more
doaj   +1 more source