Results 91 to 100 of about 201,930 (301)

Robotic single-port plus one assist port splenectomy in an adult: a case report with video

open access: yesJournal of Minimally Invasive Surgery
Minimally invasive techniques are increasingly used in hepatobiliary and pancreatic surgeries, but robotic single-port (SP) splenectomy remains uncommon due to the rarity of splenic diseases.
Su Hyung Park   +2 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Ureteroscopic Lithotripsy for A Surgical Clip‐Induced Renal Stone Following Laparoscopic Partial Nephrectomy

open access: yesIJU Case Reports
Introduction Surgical clips used in laparoscopic and robot‐assisted surgeries can occasionally migrate into the upper urinary tract, serving as nidi for stone formation.
Takashi Yoshioka   +9 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Adenosine triphosphate (ATP) sampling algorithm for monitoring the cleanliness of surgical instruments. [PDF]

open access: yesPLoS One, 2023
Pontes DO   +5 more
europepmc   +1 more source

Safety, cost and environmental impact of reprocessing low and moderate risk single-use medical devices: a systematic review

open access: yesGMS Hygiene and Infection Control
Objectives: Estimate the safety, financial and environmental impacts of reprocessing low and moderate risk single-use medical devices (SuMDs). Methods: Systematic review (PROSPERO ID: CRD42022365642) of primary studies of patients receiving ...
Niamh McGrath   +6 more
doaj   +1 more source

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