Results 131 to 140 of about 3,035,399 (352)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Therapeutic strategies for synchronous and multiple liver metastases from colorectal cancer

Oncology Reviews, 2012
Metastasis in the liver is one of the most critical factors in the prognosis of patients with colorectal cancer. The incidence of synchronous liver metastasis has been found to be approximately 20-25%, but the optimal timing of surgical resection remains
Shinji Osada, Hisashi Imai, Yoshiyuki Sasaki, Yoshihiro Tanaka, Nobuhisa Matsuhashi, Naoki Okumura, Michitaka Nagase, Kenichi Nonaka, Kazuhiro Yoshida   +8 more
doaj   +1 more source

Validation of a Multivariate Serum Profile for Epithelial Ovarian Cancer Using a Prospective Multi-Site Collection [PDF]

, 2010
In previous studies we described the use of a retrospective collection of ovarian cancer and benign disease samples, in combination with a large set of multiplexed immunoassays and a multivariate pattern recognition algorithm, to develop an 11-biomarker ...
Beth Y. Karlan, Brian C. Mansfield, Brigitte E. Miller, Eva Chalas, Glenn E. Bigsby, Greg P. Bertenshaw, James F. Barter, James P. Mapes, James W. Orr, Jinghua Zhao, Katharine J. Bergstrom, Laurie L. Stephen, Lynda D. Roman, Michael E. McCollum, Partha Seshaiah, Paul A. DiSilvestro, Ping F. Yip, Robert W. Holloway, Ronald D. Alvarez, Suraj Amonkar, Tzong-Hao Chen   +20 more
core   +1 more source

A literature review on surgery for cervical vagal schwannomas [PDF]

, 2015
Cervical vagal schwannoma is a benign, slow-growing mass, often asymptomatic, with a very low lifetime risk of malignant transformation in general population, but diagnosis is still a challenge.
A Peyvandi, A Ziadi, AL Moroni, BK Lahoti, D Biswas, E Langner, EN Callum, GC Kang, Giada Pattaro, Gianfranco Silecchia, Giuseppe Cavallaro, H Liu, J Valentino, JL Roh, KC Chiun, KR Hwang, L Rogers, Marcello Avallone, MG Chiofalo, MJ Gibber, MK Bhayani, MR Sreevatsa, NG McGuire, Olga Iorio, R Bilancia, R Matsuo, R Yasumatsu, RI Rückert, RM Lee, RS Murley, SH Kim, T Ogawa   +31 more
core   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Outcomes of minimal access cytoreductive surgery (M-CRS) and HIPEC/EPIC vs. open cytoreductive surgery (O-CRS) and HIPEC/EPIC in patients with peritoneal surface malignancies: a meta-analysis

Pleura and Peritoneum
Minimal Access Surgery (MAS) has shown better peri-operative outcomes with equivalent oncological outcomes in gastrointestinal and thoracic oncology. Open CRS (O-CRS) procedure accompanies inevitable and significant surgical morbidity in patients.
Pawar Ajinkya, Warikoo Vikas, Salunke Abhijeet, Sharma Mohit, Pandya Shashank, Bhardwaj Amol, KS Sandeep, Aaron Jebin   +7 more
doaj   +1 more source

Nutritional Outcomes of patients Undergoing Resection for upper gastroIntestinal cancer in AuStralian Hospitals (NOURISH): protocol for a multicentre point prevalence study: protocol for a multicentre point prevalence study [PDF]

, 2020

core   +1 more source

Borderline Ovarian Malignancies : A Single Institute Retrospective Study. [PDF]

, 2013
Background: Borderline ovarian tumors are histologically characterized as epithelial tumors with a stratified growth pattern but without destructive stromal invasion.
Bafna, UD, Bhise, R, Guruprasad, B, Kundargi, R, Pallavi, R, Rathod, R, Shakuntala, PN, Shobha, K, Umadevi, K   +8 more
core