Results 131 to 140 of about 3,580,327 (305)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Randomised preference trial of medical versus surgical termination of pregnancy less than 14 weeks' gestation

, 2009
Objectives: To determine the acceptability, efficacy and costs of medical termination of pregnancy (MTOP) compared with surgical termination of pregnancy (STOP) at less than 14 weeks’ gestation, and to understand women’s decision-making processes and ...
Kelly, T., SC Robson, T Kelly, Lie, M.L.S., Hewison, J., J Hewison, Armstrong, N ., MLS Lie, M Deverill, Howel, D., Stamp, E., CR May, Deverill, M., D Howel, E Stamp, D Howel,, May, C.R ., Robson, S.C., N Armstrong   +18 more
core   +1 more source

Why not vaginal?—Nationwide trends and surgical outcomes in low‐risk hysterectomies: A retrospective cohort study

Acta Obstetricia et Gynecologica Scandinavica
Introduction The rate of vaginal hysterectomies is declining globally. We investigated surgical techniques, outcomes, and costs in a large national cohort of benign hysterectomies with prerequisites for vaginal surgery.
Johanna Wagenius, Sophia Ehrström, Karin Källén, Jan Baekelandt, Andrea Stuart   +4 more
doaj   +1 more source

Clinical characteristics and surgical outcome analysis of quadrigeminal cistern arachnoid cysts in children: a quantitative retrospective cohort study

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To quantify the volume of quadrigeminal cistern arachnoid cysts (QACs) and hydrocephalus indicators, and analyze the clinical features of QACs in children and the efficacy of different surgical techniques, with the goal of improving ...
Liu Meiling, Bao Lei, Min Lingzhao, Wei Jia, Hua Li, Wang Xiaoqiang   +5 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Surgical treatment for acute aortic dissection with coronary malperfusion in Japan: Nationwide database analysisCentral MessagePerspective

JTCVS Open
Objective: To assess the surgical outcomes of acute aortic dissection (AAD) with coronary malperfusion (CM) in Japan through the Japan Cardiovascular Surgery Database.
Toshiki Fujiyoshi, MD, PhD, Hiraku Kumamaru, MD, ScD, Hitoshi Ogino, MD, PhD, Naoko Kinukawa, PhD, Yusuke Shimahara, MD, PhD, Noboru Motomura, MD, PhD   +5 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Surgical Correction and Outcome of Exotropia

Asia-Pacific Journal of Ophthalmology, 2015
The issue of surgical correction of exodeviations is still an open one. The article by Raiyawa et al1 entitled ‘‘Outcomes of 3 or 4 Horizontal Muscles Surgery in Large-Angle Exotropia’’ provides an opportunity for a discussion on this topic. When and how much surgery is needed for exotropia is still up to the decision of individual surgeons. Guidelines
openaire   +3 more sources