Results 121 to 130 of about 3,580,327 (305)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Traumatic Extradural Hematoma: Factors Affecting the Surgical Outcome

Journal of the Dow University of Health Sciences, 2016
Objective: To determine the factors affecting surgical outcome of traumatic intracranial extradural hematoma in Civil Hospital Karachi. Head injury is a leading cause of death in young age group.
Muhammad Faaiq Ali, atiq ahmed khan, Ahmed Khan, Muhammad Imran, Farrukh Zulfiqar, Muhammad Muzaffer Uddin, Junaid Ashraf   +6 more
doaj  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Short- to intermediate-term surgical outcome of Keiki Mehta valve implantation in refractory glaucoma

Indian Journal of Ophthalmology
Background: Keiki Mehta body pressure (BP) valve is a glaucoma drainage device that works on the simple mechanism of body pressure. Purpose: To evaluate the short- to intermediate-term efficacy and safety of Keiki Mehta valve implantation in treating ...
Ankita Mitra, Tania Ray Bhadra
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Considerations for learning-oriented monitoring and evaluation with Outcome Mapping [PDF]

, 2009
Outcome Mapping (OM) was developed both as a planning and a monitoring tool. And while it has been used successfully for both purposes, this brief focuses on OM as a monitoring and evaluation (M&E) approach.
Ambrose, Kaia
core   +1 more source

5-Year Experience in Saliva Control Clinic in a Tertiary Center: Outcome of Drooling in Children

B-ENT
Background: Drooling beyond age 4 is pathological, requiring investigation and intervention. The lack of a standardized approach to treating children with drooling poses a challenge in managing these patients.
Jeyasakthy Saniasiaya, Ed Toll, Graeme Van Der Meer   +2 more
doaj   +3 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Integration of patient-reported outcome measures with key clinical outcomes after immediate latissimus dorsi breast reconstruction and adjuvant treatment

, 2013
Background: linical evidence on patient-reported outcome measures (PROMS) in breast reconstruction is lacking. The aim of this study was to evaluate PROMs in implant-assisted latissimus dorsi (LDI) or tissue-only autologous latissimus dorsi (ALD) flap ...
Haviland, J.S., Betambeau, N., Balta, V., Reece-Smith, A., Benson, J., Winters, Z.E.   +5 more
core   +1 more source