Results 201 to 210 of about 1,041,127 (314)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The informed consent process for surgical procedures: perspectives of patients and next-of-kins in a lower middle-income country. [PDF]

BMC Med Ethics
Nsaful J, Attah D, Sefogah PE, Dedey F, Bediako-Bowan A, Amoako J, Amoah SK, Donkoh IB, Clegg-Lamptey JN.   +8 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Efficacy of a Superficial Cervical Plexus Block as an Alternative to General Anesthesia for Mandibular and Perimandibular Surgical Procedures: A Systematic Review. [PDF]

Cureus
Hiran O, Kale T, Pathak R, Bichile R, Vadher K.   +4 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

"5G wireless + wired network"-based multi-console robotic telesurgery: adaptability to complex surgical procedures and diverse network infrastructures-a case report. [PDF]

Transl Androl Urol
Ye Z, Ding Y, Xu W, Xie Y, Qin M, Fan J, Cui L, Li N, Qiao X, Fang Y, Ji Z, Yang Y, Dong J.   +12 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

A comparative study of endodontic treatment versus surgical procedures in managing dental trauma and tooth avulsion. [PDF]

Bioinformation
Talnia S, Giri R, Dubey V, Rao SD, Sharma J, Mohanty R.   +5 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

The Usefulness of Over-the-Scope Clips for Managing Gastrointestinal Complications of Endoscopic or Surgical Procedures: The SAGA-OTSC Registry Study. [PDF]

JGH Open
Yamaguchi D, Akutagawa T, Yukimoto T, Tominaga N, Miyahara K, Kawakubo H, Morita R, Okamoto N, Fujimura Y, Sadashima K, Takedomi H, Shimamura T, Tsuruoka N, Sakata Y, Shimoda R, Esaki M.   +15 more
europepmc   +1 more source