Results 211 to 220 of about 3,411,041 (254)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Continuous vs interrupted direct oral anticoagulants for minimal bleeding-risk surgical procedures-a systematic review and meta-analysis. [PDF]

Res Pract Thromb Haemost
Xiang A, Popatia S, Sadafi SL, Rao M, Shaikh A, Nowrouzi M, Li A, Eshaghpour A, Crowther M.   +8 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Is Perioperative Antibiotic Prophylaxis Necessary for Pediatric and Adolescent ESIN Osteosyntheses?-A Retrospective Analysis of 939 Surgical Procedures. [PDF]

Children (Basel)
Hundhausen L, Wulbrand C, Scheerer-Harbauer E, Sperling P, Memmel C, Hanke A.   +5 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Assessing Artificial Intelligence (AI) in Patient Education: Evaluating Accuracy and Readability of Responses on Surgical Procedures for Patellar Tendon Rupture. [PDF]

Cureus
Guirgus M, Giammanco PA, Collins C, Trivedi S, Rice RC, Nayak R, Cowley T, Baird S, Gulbrandsen M, Elsissy J.   +9 more
europepmc   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

A Retrospective Comparison of Oncologic and Staging Outcomes Between Surgical Procedures-Video-Assisted Thoracoscopic Surgery Versus Thoracotomy in Pulmonary Adenocarcinoma. [PDF]

Medicina (Kaunas)
Tanase BC, Horvat T, Burlacu A, Chitoran E, Rotaru V, Pătrașcu T, Simion L.   +6 more
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Assessment of the Quality and Reliability of Social Media Videos for Patient Information on Common General Surgical Procedures. [PDF]

Surg Innov
Omar N, Elgharably N, Lam K.
europepmc   +1 more source