Results 51 to 60 of about 1,872,691 (256)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Dynamic stiffness of articular cartilage and potential repair materials [PDF]

, 2012
Cartilage has limited potential for self repair. Therefore, articular cartilage lesions often lead to early osteoarthritis. Early clinical results of cartilage replacement procedures such as autologous matrix-induced chondrogenesis (AMIC) seem promising,
Ronken, Sarah
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Essential Surgery at the District Hospital: A Retrospective Descriptive Analysis in three African Countries. [PDF]

, 2010
Surgical conditions contribute significantly to the disease burden in sub-Saharan Africa. Yet there is an apparent neglect of surgical care as a public health intervention to counter this burden.
Macfarlane Sarah B., Andreas Wladis, Galukande, Moses, von Schreeb, Johan, Ana Romàn Quiñones, Vaz Fernando, de Miranda Helder, Wladis Andreas, McCord, Colin, Sarah B Macfarlane, Luboga, Sam, S Khady Ndao-Brumblay, Ozgediz Doruk, Moses Galukande, Colin McCord, Peter C Rockers, Mbembati Naboth, Mbembati, Naboth, Debas, Haile T, Ndao-Brumblay S. Khady, von Schreeb Johan, McCord Colin, Naboth Mbembati, Margaret E Kruk, Kruk, Margaret E, Sam Luboga, Wladis, Andreas, Quiñones, Ana Romàn, Luboga Sam, Matovu, Alphonsus, Rockers, Peter C, de Miranda, Helder, Debas Haile T., Alphonsus Matovu, Galukande Moses, Matovu Alphonsus, Johan von Schreeb, Rockers Peter C., Ndao-Brumblay, S Khady, Ozgediz, Doruk, Doruk Ozgediz, Fernando Vaz, Vaz, Fernando, Macfarlane, Sarah B, Haile T Debas, Kruk Margaret E., Quiñones Ana Romàn, Helder de Miranda   +47 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Surgical Repair of a Unileaflet Mitral Valve: A Rare Congenital Abnormality and a Novel Surgical Approach

, 2020
Congenital malformations of the mitral valve (MV) are rare, and the majority are detected in infancy and are associated with significant mortality.1 In particular, descriptions of unileaflet MV (ULMV; either partial or complete leaflet agenesis) are ...
Prasad, Sandhir B, Tomlinson, Stephen, Dahiya, Arun, Lo, Ada, Jalali, Homyaoun, Arasaratnam, Kisoth   +5 more
core   +1 more source

Jet flow aneurysm of inferior mesenteric artery

Indian Journal of Vascular and Endovascular Surgery, 2020
A 56-year-old male was evaluated for postprandial abdominal pain and was detected to have an inferior mesenteric artery (IMA) aneurysm associated with critical ostial stenosis of the celiac and superior mesenteric arteries.
Sam Pon Raj, Edwin Stephen, Albert Kota, Vimalin Samuel, Dheepak Selvaraj, Prabhu Premkumar, Sunil Agarwal   +6 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Identification of risk factors by systematic review and development of risk-adjusted models for surgical site infection [PDF]

, 2011
Background: Surgical site infections (SSIs) are complications of surgery that cause significant postoperative morbidity. SSI has been proposed as a potential indicator of the quality of care in the context of clinical governance and monitoring of the ...
Wilson, AP, Pearson, A. (Andrew), ZH Krukowski, Bruce, J, Krukowski, Zygmunt H., Gibbons, C., Pearson, A, Lamping, Donna Louise, Reeves, BC, AP Wilson, DL Lamping, J Wilson, Krukowski, ZH, Lamping, DL, J Carpenter, Krukowki, ZH, J Bruce, Carpenter, J., Gibbons, C, A Pearson, Wilson, J, Wilson, A. P. (A. Peter), BC Reeves, Reeves, B. C., Wilson, Jennie, RGN, C Gibbons, Bruce, J. (Julie), Carpenter, J   +27 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source