Results 61 to 70 of about 3,958,137 (292)
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Frontiers in SurgeryObjectiveDue to the risk of bleeding and other related complications, severe thrombocytopenia (PLT ≤ 30 × 109/L) has been regarded as a relative contraindication for splenectomy in patients with liver cirrhosis. This study aimed to investigate the impact
Huicong Min +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
MedicinaBackground and Objectives: Borderline ovarian tumours (BOTs) predominantly affect women of reproductive age. Following concerns about minimally invasive surgery (MIS) in cervical cancer, the oncological safety of the surgical approach in BOTs requires ...
Mohamed Abdelwanis Mohamed Abdelaziz +6 more
doaj +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Frontiers in ImmunologyBackgroundLandmark trials have established the surgical feasibility of neoadjuvant immunotherapy plus chemotherapy (NICT) in gastric and esophageal cancers, yet data specific to the narrow anatomical confines of the gastroesophageal junction (GEJ) remain
Huiliang Zhang +3 more
doaj +1 more source
Quality and Safety in Surgical Care
Annals of Surgery, 2006 DR. HIRAM C. POLK, JR. (Moderator): The subject of the panel this morning is obviously a paraphrase and derivative of what I talked to you about yesterday.1 If you listened to any part of the scientific program, you now are aware that there are a dozen or more people in this Association who are directly and personally involved in this quality issue ...
Hiram C, Polk +5 more
openaire +3 more sources
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
The use of checklists in surgery is a best practice.1 There is a plethora of evidence that suggests using the WHO Surgical Safety Checklist (SSC) reduces complications such as pneumonia,2 intraoperative blood loss,2 3 sepsis,2 unplanned intubation,2 ...
Ziemba, Justin Bradley +1 more
core +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source