Results 61 to 70 of about 982,608 (401)

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Prophylactic Versus Therapeutic Antibiotic Therapy Following Appendicectomy

Diyala Journal of Medicine, 2018
  Background: In the first 4 hours after a breach in an epithelial surface and underlying connective tissues made during surgery or trauma, there is a delay before host defences can become mobilised through acute inflammatory, humeral and cellular ...
Muqdad Fuad Abdulkareem, Humamalddin Edan Hussein   +1 more
doaj   +2 more sources

Risk factors for deep surgical site infection following thoracolumbar spinal surgery

Journal of Neurosurgery : Spine, 2019
OBJECTIVE Surgical site infection (SSI) following spine surgery causes major morbidity and greatly impedes functional recovery. In the modern era of advanced operative techniques and improved perioperative care, SSI remains a problematic complication ...
Hansen Deng, A. Chan, Simon G. Ammanuel, A. Chan, Taemin Oh, Henry C Skrehot, Kaleb Edwards, S. Kondapavulur, A. Nichols, Catherine Liu, J. Yue, S. Dhall, A. Clark, D. Chou, C. Ames, P. Mummaneni   +15 more
semanticscholar   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Risk factors associated with surgical site infection after breast surgery [PDF]

Reviews in Clinical Medicine, 2015
Breast surgical site infection is not only one of the main causes of the morbidity and mortality of cases under different types of surgeries, but also it results in longer hospitalization and additional expenses.
Seyed Esmael Nezhadhoseini, Kazem Fotohi, Mohammad Vejdani   +2 more
doaj   +1 more source

Surgical Site Infection

, 2020
Surgical site infections (SSIs) remain a significant source of postoperative morbidity throughout the world. Surgeons operating in resource-poor areas face the added challenges of patient malnutrition, inconsistent access to antimicrobials and underdeveloped patient and bacterial resistance surveillance systems. Nonetheless, adherence to sound surgical
Emmanuel A. Ameh, David H. Rothstein, Sharon Cox, Abdulrasheed A Nasir   +3 more
openaire   +2 more sources

Association of Mechanical Bowel Preparation and Oral Antibiotics Before Elective Colorectal Surgery With Surgical Site Infection

JAMA Network Open, 2018
Key Points Question Which approach is best to reduce surgical site infections and anastomotic leak in colorectal surgery: mechanical bowel preparation with oral antibiotics, oral antibiotics only, mechanical bowel preparation only, or no preparation ...
J. Toh, K. Phan, K. Hitos, N. Pathma-Nathan, T. El‐Khoury, A. Richardson, Gary Morgan, A. Engel, G. Ctercteko   +8 more
semanticscholar   +1 more source

Incidence of surgical site infection following mastectomy with and without immediate reconstruction using private insurer claims data [PDF]

, 2015
OBJECTIVE: The National Healthcare Safety Network classifies breast operations as clean procedures with an expected 1–2% surgical site infection (SSI) incidence.
Ball, Kelly E, Fox, Ida K, Fraser, Victoria J, Margenthaler, Julie A, Mines, Daniel, Nickel, Katelin B, Olsen, Margaret A, Wallace, Anna E   +7 more
core   +2 more sources

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

A randomized controlled trial comparing large versus small stitch incision closure in gynaecological malignancies (CLaSSIC Study)

Cancer Treatment and Research Communications
Objective: The study aimed to compare Small Stitch Closure (SSC) and Large Stitch Closure (LSC) techniques for reducing incisional ventral hernia (IVH) and surgical site infection (SSI) rates in gynaecological malignancies. Methods: We conducted a single-
Priya Bhati, Monal Garg, Saumya Gupta, Hawwa Hana, Anandita Anandita, Sheejamol V S   +5 more
doaj   +1 more source