Results 81 to 90 of about 548,621 (295)

A study of organisms causing surgical site infections and their antimicrobial susceptibility in a tertiary care Government Hospital

Indian Journal of Pathology and Microbiology, 2015
Background: Surgical site infection (SSI) is one of the most common postoperative complication and causes significant postoperative morbidity and mortality.
Aniruddha S Mundhada, Sunita Tenpe
doaj   +1 more source

Cefazolin Prophylaxis for Total Joint Arthroplasty: Obese Patients Are Frequently Underdosed and at Increased Risk of Periprosthetic Joint Infection [PDF]

, 2018
Background One of the most effective prophylactic strategies against periprosthetic joint infection (PJI) is administration of perioperative antibiotics. Many orthopedic surgeons are unaware of the weight-based dosing protocol for cefazolin.
Greenky, Max R., Kheir, Michael M., Parvisi, Javad, Rondon, Alexander J., Shohat, Noam, Tan, Timothy L.   +5 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Surgical Site Infection

The Professional Medical Journal, 2017
Objectives: To compare the frequency of surgical site infection after primaryand delayed primary wound closure in dirty abdominal wounds. Study Design: Randomizedcontrolled trial. Duration and Setting: This study was carried out over a period of six monthsfrom 07-02-2014 to 06-08-2014 in the department of surgery combined military hospital Quetta ...
Syed Muhammad Asar Hussain, Saadat Ali Janjua, Amna Fareed, Asrar Ahmad, Irum Saleem   +4 more
openaire   +3 more sources

Surgical Prophylaxis: Is it Always Needed in Orthopaedics Practice

Journal of Clinical Orthopaedics
Introduction: The objectives of this study were to assess the need for antibiotic prophylaxis in soft-tissue surgeries of short duration without usage of implant in the field of orthopedics. Materials and Methods: A prospective and comparative randomized
Swati Lalchandani, Rajesh Yadav, Rakesh Parmar, Rajesh Lalchandani, Shashikant Prakash   +4 more
doaj   +1 more source

Implantation of subcutaneous heart rate data loggers in southern elephant seals (Mirounga leonina) [PDF]

, 2017
Unlike most phocid species (Phocidae), Mirounga leonina (southern elephant seals) experience a catastrophic moult where they not only replace their hair but also their epidermis when ashore for approximately 1 month.
Ancel, André, Chaise, Laureline L., Gallon, Susan L., Gilbert, Caroline, Laske, Timothy G., McCafferty, Dominic J., Paterson, William, Théry, Marc   +7 more
core   +3 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Surgical Management of Diabetic Foot Ulcers: A Tanzanian University Teaching Hospital Experience. [PDF]

, 2011
\ud \ud Diabetic foot ulcers (DFUs) pose a therapeutic challenge to surgeons, especially in developing countries where health care resources are limited and the vast majority of patients present to health facilities late with advanced foot ulcers.
Chalya, Phillipo L, Mabula, Joseph B, Dass, Ramesh M, Kabangila, Rodrick, Jaka, Hyasinta, McHembe, Mabula D, Kataraihya, Johannes B, Mbelenge, Nkinda, Gilyoma, Japhet M   +8 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Implementation of a surgical unit-based safety programme in African hospitals: a multicentre qualitative study

Antimicrobial Resistance and Infection Control, 2019
Background A Surgical Unit-based Safety Programme (SUSP) has been shown to improve perioperative prevention practices and to reduce surgical site infections (SSI).
Lauren Clack, Ursina Willi, Sean Berenholtz, Alexander M. Aiken, Benedetta Allegranzi, Hugo Sax   +5 more
doaj   +1 more source