Results 41 to 50 of about 4,754,620 (235)

The impacts of androgen receptor on treatment response and survival in triple-negative breast cancer treated with neoadjuvant chemotherapy: a single-center retrospective study

Frontiers in Oncology
BackgroundTriple-negative breast cancer (TNBC) is an aggressive subtype characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and HER2 expression, resulting in limited treatment options.
Seda Karaçam, Mehmet Furkan Sağdıç, Zarife Melda Bulut, Suat Kutun, Cihangir Özaslan   +4 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Intermediate-Term Oncological, Anastomotic and Nutritional Outcomes of the Sutureless L-Shaped Esophagojejunostomy with Endoscopic Assistance (SLEJ) in Totally Laparoscopic Total Gastrectomy: A Follow-Up Analysis of This Technique

Medicina
Background and Objectives: Intra-corporeal esophagojejunostomy after totally laparoscopic total gastrectomy (TLTG) remains one of the most technically demanding steps of minimally invasive gastric surgery.
Sevket Baris Morkavuk, Sumeyra Guler, Ibrahim Burak Bahcecioglu, Mujdat Turan, Gokhan Giray Akgul, Kubilay Kenan Ozluk, Erdi Aydin, Kahraman Dinler, Cagdas Karaman, Mehmet Ali Gulcelik   +9 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Effect of the COVID-19 Pandemic on the Training of Surgical Resident Doctors at the University College Hospital, Ibadan, Nigeria [PDF]

Background: Studies in many countries have reported that the coronavirus disease 2019 (COVID-19) pandemic disrupted surgical residency training. While a few qualitative studies have been conducted to investigate the effect of this disruption in Nigeria ...
Anuoluwapo Victor Adeyemi, Gladys Zugwai Ibrahim, Ideyonbe Samuel Eseile, Babatunde Isaac Ademusire, Toluwanimi Oyebanji, Adefemi Oladiran Afolabi, Opeoluwa Samuel Adefarati, Aishat Temitope Alonge   +7 more
core   +1 more source

Trabeculectomy Training: Review of Current Teaching Strategies

Advances in Medical Education and Practice, 2020
Andrew Walkden,1,2 Leon Au,1,2 Cecilia Fenerty1,2 1Manchester Royal Eye Hospital, Manchester University Foundation Trust, Manchester, UK; 2Medical Academic Health Sciences Centre, University of Manchester, Manchester, UKCorrespondence: Andrew ...
Walkden A, Au L, Fenerty C
doaj  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Surgical treatment of diabetic macular edema

Российский офтальмологический журнал
Diabetic retinopathy (DR) and diabetic macular edema (DME) present a serious medical and social issue of modern society. DME is one of the most common complications of DR and a frequent cause of a sudden decrease in visual acuity and the onset of ...
R. R. Fayzrakhmanov, O. A. Pavlovsky, M. A. Lukinykh, N. S. Egorova   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

De-escalation of axillary surgery in early breast cancer: translating ACOSOG Z0011 study into clinical practice for breast-conserving surgery patients with positive sentinel lymph node biopsy

BMC Cancer
Purpose This retrospective study aimed to compare patients eligible for the Z0011 study with and without axillary lymph node dissection (ALND) by overall survival (OS), disease-free survival (DFS), and loco-regional recurrence.
Mehmet Furkan Sağdıç, Burak Dinçer, Cihangir Özaslan   +2 more
doaj   +1 more source