Results 131 to 140 of about 2,026,225 (318)

Corrigendum: PPy@Fe3O4 nanoparticles inhibit the proliferation and metastasis of CRC via suppressing the NF-κB signaling pathway and promoting ferroptosis

Frontiers in Bioengineering and Biotechnology, 2023
Zhilong Yu, Shanshi Tong, Chenyi Wang, Zizhen Wu, Yingjiang Ye, Shan Wang, Kewei Jiang   +6 more
doaj   +1 more source

Lymphatic vessel: Origin, heterogeneity, biological functions and therapeutic targets

Signal Transduction and Targeted Therapy
Lymphatic vessels, comprising the secondary circulatory system in human body, play a multifaceted role in maintaining homeostasis among various tissues and organs.
Zhaoliang Hu, Xushi Zhao, Zhonghua Wu, Bicheng Qu, Minxian Yuan, Yanan Xing, Yongxi Song, Zhenning Wang   +7 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Corrigendum: Yu et al. PPy@Fe3O4 nanoparticles inhibit the proliferation and metastasis of CRC via suppressing the NF-κB signaling pathway and promoting ferroptosis

Frontiers in Bioengineering and Biotechnology, 2022
Zhilong Yu, Shanshi Tong, Chenyi Wang, Zizhen Wu, Yingjiang Ye, Shan Wang, Kewei Jiang   +6 more
doaj   +1 more source

Racial Differences in Survival after Surgical Treatment for Melanoma

, 2011
Background: Surgical-treatment outcomes for melanoma in African Americans are poorly characterized as a result of low incidence of melanoma among African Americans.
Jeffe, Donna B., Liu, Ying, Fields, Ryan C., Karen Kadela Collins, Ying Liu, Collins, Karen Kadela, Baptiste, Dadrie, Dadrie Baptiste, Moley, Jeffrey, Ryan C. Fields, Donna B. Jeffe, Jeffrey Moley   +11 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Experiences of current practice, priorities and strategies for enabling meaningful consumer and community involvement collaborations in health and medical research in Queensland, Australia

Research Involvement and Engagement
Background Consumer and community involvement (CCI) in health and medical research is essential for ensuring meaningful and transferrable research.
Lisa Anemaat, Kimberley A. Baxter, Emmah Doig, Jennifer Muller, Nadine E. Foster, Jessica Schults, Karina R. Charles, Adrienne Young, Silvia Manzanero, Tanya Smyth, Michael O’Sullivan, Gail Robinson, Rachel Latimore, Diana Tam, David A. Copland   +14 more
doaj   +1 more source

The clinical features and surgical treatment of acute septic arthritis in Malawian children.

, 2006
Introduction: Untreated and poorly treated septic arthritis in children is a major cause of orthopaedic pathology in Malawi and the rest of sub Saharan Africa, yet little has been published on its early treatment, or its incidence, clinical features and ...
Lavy, C.B.D.
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source