Results 161 to 170 of about 106,217 (219)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

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SURGICAL TREATMENT OF THYROTOXICOSIS

The Lancet, 1976
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Wilkin, TJ, Hedley, AJ
openaire   +3 more sources

Surgical Treatment of Sterility

American Journal of Obstetrics and Gynecology, 1949
Tubal occluson accounts primarily for primary sterility which must be handled from pressure methods first then if treatment fails resort to surgery. Initially screening is performed by using the Rubins test and if gas is not passed for 2 sucessive months then lipiodol tubal insufflation is performed.
R N, RUTHERFORD, H M, LAMBORN, A L, BANKS   +2 more
openaire   +2 more sources

Surgical treatment of rhinophyma

Plastic and Reconstructive Surgery, 1961
The term "rhinophyma" is derived from the Greek, rhis , 'nose' and phyma , 'growth.' It is a benign condition which, microscopically, shows enlarged cystic sebaceous glands, marked fibrosis, and vascular dilation. Rhinophyma is usually seen in males over 50 years of age. The male-female ratio is 10 to 1.
J T, DICKINSON, E, ADAMOPOULOS
openaire   +2 more sources

Surgical Treatment of Acromegaly

Acta Oto-Laryngologica, 1960
Acromegaly is a disabling and often fatal disease. As it is usually caused by a pituitary tumour, its manifestations should be arrested by removal of the tumour. Earlier surgical treatment has seldom produced lasting improvement, since radical removal has not been done, partly to avoid the appearance of panhypopituitarism.
C.-A. Hamberger, G. Hammer, G. Norlén, B. Sjögren, C.-A. Hamberger   +4 more
openaire   +3 more sources

Surgical Treatment of Dysphagia

Physical Medicine and Rehabilitation Clinics of North America, 2008
The role of surgery in the management of dysphagia is clear in some areas and controversial in others. Evaluation for the causes of dysphagia can elucidate conditions in which surgery can improve safety, quality of life, or both. Surgical therapy, when indicated, is safe and effective for many causes of dysphagia.
Liat, Shama, Nadine P, Connor, Michelle R, Ciucci, Timothy M, McCulloch   +3 more
openaire   +2 more sources

Surgical treatment of tympanosclerosis

Oto-Rhino-Laryngology, 1995
Tympanosclerosis as a cause of conductive hearing loss may require corrective surgery in carefully selected cases, although results of treatment have been controversial and must be viewed with caution. Currently available surgical techniques are reviewed and outcomes discussed.
A G, Gibb, Y T, Pang
openaire   +2 more sources