Results 41 to 50 of about 1,608,036 (295)
Towards structuring contextual information for workflow-driven surgical assistance functionalities
Current Directions in Biomedical Engineering, 2015 A workflow-driven cooperative working environment needs to be established in order to successfully unburden the surgeon and the OR staff from technical configuration and information-seeking tasks.
Franke Stefan, Neumuth Thomas
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Frontiers in MedicineIntroductionThe curriculum for a da Vinci surgeon in gynecology requires special training before a surgeon performs their first independent case, but standardized, objective assessments of a trainee’s workflow or skills learned during clinical cases are ...
Felix Neis +10 more
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Challenges in implementing a digital pathology workflow in surgical pathology
Human Pathology Reports, 2022 The rate of digital pathology adoption had been slow until the COVID-19 pandemic served as catalyst, demonstrating the possibilities of saving time and money by converting glass slides into whole slide images (WSI) and thus making them available to all ...
Giovani Lujan, Zaibo Li, Anil V. Parwani
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Current Directions in Biomedical Engineering, 2015 An essential aspect for workflow management support in operating room environments is the description and visualization of the underlying processes and activities in a machine readable format as Surgical Process Models (SPM).
Neumann Juliane, Neumuth Thomas
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Sensors, 2021 During the last decade, orthopedic oncology has experienced the benefits of computerized medical imaging to reduce human dependency, improving accuracy and clinical outcomes.
Rafael Moreta-Martinez +5 more
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FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source