Results 81 to 90 of about 535,677 (366)

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Appropriateness and pharmacoeconomics of surgical antimicrobial prophylaxis in open reduction internal fixation surgery practiced in a tertiary hospital compared to recommendations in the national center for disease control guidelines

Perspectives in Clinical Research, 2019
Context: Surgical site infections are frequently observed despite the availability of national guideline on surgical antimicrobial prophylaxis (SAP). These infections increase patient morbidity, mortality, and direct and indirect health-care costs.
Priyanka Kumari, Jayaram B Siddegowda, Vasundara Krishnaiah   +2 more
doaj   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Local antituberculosis treatment in nonhealing chronic surgical site tuberculosis: A novel approach to cure nonhealing wound!

Annals of Medical Science and Research
Tuberculosis most commonly affects the lungs and less than 20% of cases showed extrapulmonary involvement. Tuberculosis at the surgical site is described in the medical literature with very few cases of cesarean section at the incision site.
Shital Patil, Deepak Patil, Shubhangi Khule, Gajanan Gondhali   +3 more
doaj   +1 more source

Does plastic incise drape prevent recolonization of endogenous skin flora during lumbar spine procedures?

International Journal of Preventive Medicine, 2019
Background: The aim of this study was to compare the PID with bare skin (without PID) regarding bacterial recolonization and bacterial regrowth of the adjacent skin of surgical incision in lumbar spine surgery patients.
Mohammadreza Zarei, Negin Larti, Homayoun Tabesh, Mohammad Ghasembandi, Akram Aarabi   +4 more
doaj   +1 more source

Infection in prosthetic material [PDF]

, 2015
Surgical site infection (SSI) occurs when a wound created as part of a surgical procedure becomes infected. SSI is one of the most common healthcare-associated infections and occurs in approximately 5% of patients undergoing a surgical procedure. SSI may
Chetter, Ian, Smith, George
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Combined Phase 1/2a Initial Clinical Safety Trials and Proof‐of‐Concept Assessment of a Novel Antimicrobial Peptide KSL‐W Anti‐Plaque Chewing Gum

Clinical and Experimental Dental Research
Objectives The effective control of dental plaque is crucial for oral health, given that pathogenic bacteria in plaque are the primary cause of dental caries.
J. Brett Ryan, Brian J. Kirkwood, Kai P. Leung   +2 more
doaj   +1 more source

Morbidity following Surgical Management of Vulval Cancer. [PDF]

, 2012
The objective of this study was to know the complications following vulvectomy and inguinofemoral lymphadenectomy including the time taken to complete wound healing.
Bafna, UD, Challa, VR, Gurubasavanagoud, Y, Reddihalli, P, Umadevi, K   +4 more
core  

Management of Forehead Scars [PDF]

, 2017
This article provides an overview of scar management within the forehead region. It addresses the unique challenges specific to the treatment of forehead wounds. A logical, stepwise approach is used.
Bryant, Lucas M., Heffelfinger, Ryan N., Sanan, Akshay   +2 more
core   +2 more sources