Results 91 to 100 of about 179,458 (296)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
SURPLUS-VALUE AND AGGREGATE CONCENTRATION IN THE UK ECONOMY, 1987-2009 [PDF]
This paper examines the movements in the Marxian surplus-value rate using a Quantitative Marxist methodology. It examines the relationship between surplus-value and the degree of monopoly power in the UK economy using quarterly data and a proxy for ...
Bruce Philp, Vitor Leone
core
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Marie de France’s “Lais” and Troubadours Lyrics
Studia Humanitatis, 2014 The article analyses the mechanisms of troubadours’ heritage reception of the 12th century by Marie de France, the first poet who lived at the court of Henry II.
Dolgorukova Natalia Mikhailovna
doaj
Éloge et critique de l’efficience économique : Quesnay, Smith, Rousseau
Etudes EpistémèEconomic efficiency is defined in the 18th century, by Quesnay as well as by Smith, as the maximization of the surplus generated by an economy. For Quesnay, the surplus is consumed for pleasure, while for Smith it is mainly accumulated in order to ...
Claire Pignol
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Labor surplus areas (Columbus, Ohio : Online); LAUS - Labor Surplus Areas; LAUS
Description based on: Oct. 1, 2008 through Sept. 30, 2009; title from caption (viewed on Nov. 14, 2008).Lists labor surplus areas in Ohio (cities and counties), with map, and link to information on prior labor surplus ...
core +2 more sources
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
"Sustainability and Surplus" [PDF]
In this paper we present two new concepts for studying sustainability. The first is the idea of an environmentally adjusted surplus(ES). The classical concept of surplus is revised to approximate the total available discretionary income for the society ...
Haider A. Khan
core