Results 241 to 250 of about 1,277,935 (286)

Novelty as a drive of human exploration in complex stochastic environments. [PDF]

open access: yesProc Natl Acad Sci U S A
Modirshanechi A   +4 more
europepmc   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen   +12 more
wiley   +1 more source

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

open access: yesAdvanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini   +24 more
wiley   +1 more source

Do subclinical anxious and depressive symptoms affect facial emotion recognition? An exploratory investigation. [PDF]

open access: yesDement Neuropsychol
da Silva AS   +6 more
europepmc   +1 more source

Letter To The Editor. [PDF]

open access: yesFuture Sci OA
Antunes FJR.
europepmc   +1 more source

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