Results 41 to 50 of about 1,277,935 (286)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
What is value – accumulated reward or evidence?
Frontiers in Neurorobotics, 2012 Why are you reading this abstract? In some sense, your answer will cast the exercise as valuable – but what is value? In what follows, we suggest that value is evidence or, more exactly, log Bayesian evidence.
Karl eFriston +2 more
doaj +1 more source
Surprise Acts as a Reducer of Outcome Value in Human Reinforcement Learning
Frontiers in Neuroscience, 2020 Surprise occurs because of differences between a decision outcome and its predicted outcome (prediction error), regardless of whether the error is positive or negative.
Motofumi Sumiya +2 more
doaj +1 more source
Surprise, Intelligence Failure, and Mass Casualty Terrorism [PDF]
, 2006 This study aims to evaluate whether surprise and intelligence failure leading to mass casualty terrorism are inevitable. It explores the extent to which four factors - failures of public policy leadership, analytical challenges, organizational obstacles,
Copeland, Thomas Edgar
core
Detecting communities using asymptotical Surprise
, 2015 Nodes in real-world networks are repeatedly observed to form dense clusters, often referred to as communities. Methods to detect these groups of nodes usually maximize an objective function, which implicitly contains the definition of a community.
Aldecoa, R. +2 more
core +1 more source
Surprise probabilities in Markov chains [PDF]
, 2014 In a Markov chain started at a state $x$, the hitting time $\tau(y)$ is the first time that the chain reaches another state $y$. We study the probability $\mathbf{P}_x(\tau(y) = t)$ that the first visit to $y$ occurs precisely at a given time $t ...
Norris, James, Peres, Yuval, Zhai, Alex
core +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Resilience: Accounting for the Noncomputable
Ecology and Society, 2009 Plans to solve complex environmental problems should always consider the role of surprise. Nevertheless, there is a tendency to emphasize known computable aspects of a problem while neglecting aspects that are unknown and failing to ask questions about ...
Stephen R. Carpenter +3 more
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source