Results 41 to 50 of about 5,183 (178)

Plasma EC90 multiples are drug, target site and species specific—A physiologically based pharmacokinetic modelling example of nirmatrelvir central nervous system distribution

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Achieving minimum unbound drug concentration in plasma above in vitro EC90 is a common antiviral pharmacokinetic/pharmacodynamic (PK/PD) target. However, it often overlooks restricted distribution into target sites like the central nervous system (CNS), where a trough concentration above 1 × EC90 is needed.
Daan W. van Valkengoed, Xuanlin Liu, Sean N. Avedissian, Courtney V. Fletcher, Ashley N. Brown, Elizabeth C. M. de Lange, Anne‐Grete Märtson   +6 more
wiley   +1 more source

Legal Construction of Surrogacy in Indonesia Based on The Altruistic Regulation Model in Australia

Law Research Review Quarterly
Although Indonesia has regulated provisions regarding assisted  reproductive technology, there are no regulations that explicitly regulate the legality, mechanisms, or legal consequences of surrogacy.
Alya Sakila
doaj   +1 more source

“I Self‐Protect to Avoid Child Protection”: Transgender Parents' Fears of Help‐Seeking and Social Service Systems

Family Relations, EarlyView.
ABSTRACT Objective This mixed‐methods study examined transgender (trans) parents' concerns about being targeted and reported to child protective services by schools, health care providers, neighbors, and family members. Background Trans people and parents specifically may be experiencing heightened fears about interfacing with sources of potential ...
Abbie E. Goldberg, Elizabeth R. Boskey, JuliAnna Z. Smith, Ariel K. Berman   +3 more
wiley   +1 more source

Cross-Border Surrogacy Motherhood in Comparative Law and The Problem of Legal Parenthood

Public and Private International Law Bulletin, 2020
Surrogacy motherhood emerges as one of the popular topics in private international law. The reasons are that surrogacy motherhood is a complex phonemonen both in social and legal aspects and domestic legal approaches differ widely between jurisdictions ...
Cahit Ağaoğlu
doaj   +1 more source

Birth of a Mother Without Giving Birth: Experiences of Non‐Biological Mothers in Lesbian Families

Family Relations, EarlyView.
ABSTRACT Objective To explore the lived experience of non‐biological mothers in lesbian families and the meaning they attribute to the maternal experience in the absence of a biological connection. Background Non‐biological mothers in lesbian planned families construct maternal identity without pregnancy, childbirth, or genetic ties.
Yael Doft, Inbar Livnat, Maya Payes
wiley   +1 more source

Surrogacy in Islamic Jurisprudence: A Comprehensive Study of Maqasid al-Shariah and Ethical Viability According to Contemporary Mufassir [PDF]

Pharos Journal of Theology
From an Islamic Jurisprudence point of view, this research tries to examine surrogacy mostly in connection to Maqasid al-Shariah and current mufassir ideas.
Angga Tinova Yudha, Amsal Qori Dalimunthe, An Nisa Dian Rahma   +2 more
doaj   +1 more source

Scales of Knowing: Intended Parents' Deliberations on Donor Identifiability in Aotearoa New Zealand

Family Relations, EarlyView.
ABSTRACT Objective This study explored how intended parents choose among known, identifiable‐but‐unknown‐at‐conception and anonymous gamete donors. In New Zealand clinic‐based donation, donor‐conceived people can access identifying donor information at age 18, while some overseas or unregulated arrangements may permit permanent anonymity.
Sharyn Graham Davies, Carina Truyts, Nelly Martin‐Anatias   +2 more
wiley   +1 more source

Working Through (In)fertility: An Autoethnography of Fertility Treatment, Employment, and Institutional Nonrecognition in Ireland

Gender, Work &Organization, EarlyView.
ABSTRACT Infertility predominantly affects people of working age, yet the experience of pursuing treatment while in employment rarely enters the workplace as a legitimate concern. Drawing on a longitudinal autoethnography of fertility treatment undertaken alongside an early academic career in Ireland between 2017 and 2024, and informed by policy, legal,
Valentina Paolucci
wiley   +1 more source

Protection of rights and legal remedies for surrogate mothers in China

Humanities & Social Sciences Communications, 2023
Surrogacy has grown significantly as an underground industry in China over the last two decades. Accordingly, an increasing number of surrogate mothers are being bound by surrogacy contracts.
Yue Zhao
doaj   +1 more source

Company‐Sponsored Fertility Benefits: A Gift‐Exchange and Contextual Intersectionality Informed “FAiRE” Framework Guiding Design and Implementation

Gender, Work &Organization, EarlyView.
ABSTRACT Managing the work‐fertility interface is a major challenge for organizations when implementing fertility policies. These policies cover a broad spectrum of areas including clinical treatments, preservation and storage of eggs and sperm, preimplantation and diagnostics, and non‐clinical family‐building assistance. They also differ from standard
Clíodhna MacKenzie, Thomas Garavan, Elaine O'Brien   +2 more
wiley   +1 more source