Results 31 to 40 of about 364,351 (266)
A Surrogate Modeling Approach for the Development of Biorefineries
Frontiers in Chemical Engineering, 2020 Biorefinery processes are challenged to make effective use of commercial flowsheeting software. Challenges include the lack of property data, complexity of raw materials, and emerging non-conventional processes and technologies.
Aikaterini D. Mountraki +4 more
doaj +1 more source
Neural Networks for Improving Wind Power Efficiency: A Review
Fluids, 2022 The demand for wind energy harvesting has grown significantly to mitigate the global challenges of climate change, energy security, and zero carbon emissions. Various methods to maximize wind power efficiency have been proposed.
Heesoo Shin +2 more
doaj +1 more source
Generalized Linear Models with Covariate Measurement Error and Zero-Inflated Surrogates
MathematicsEpidemiological studies often encounter a challenge due to exposure measurement error when estimating an exposure–disease association. A surrogate variable may be available for the true unobserved exposure variable.
Ching-Yun Wang +3 more
doaj +1 more source
Research Progress in Viral Inactivation Utilizing Human Norovirus Surrogates
Frontiers in Sustainable Food Systems, 2018 Human noroviruses are the leading cause of foodborne illness globally. Numerous challenges in control of these viruses exist due to multiple viral characteristics: the ability to environmentally persist for over a month; relatively low infectious dose ...
Pragathi Kamarasu +2 more
doaj +1 more source
Frontiers in ImmunologyIntroductionThere is debate on which are the best surrogate endpoint and metric to capture treatment effect on overall survival (OS) in RCTs testing immune-checkpoint inhibitors (ICIs).MethodsWe systematically searched for RCTs testing ICIs in patients ...
Isabella Sala +18 more
doaj +1 more source
Journal of Global Infectious DiseasesIntroduction: Identifying hemagglutination inhibition (HI) antibody titers as a key immune correlate of protection (CoP) is crucial for developing, licensing, and monitoring the ongoing effectiveness of new influenza vaccines.
Fenny Ong +7 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2022 BackgroundThe neuroprotective effect of remote ischemic preconditioning (RIPC) in patients undergoing elective cardiopulmonary bypass (CPB)-assisted coronary artery bypass graft (CABG) or valvular cardiac surgery remains unclear.MethodsA randomized ...
Shouqiang Zhu +7 more
doaj +1 more source
On the individual surrogate paradox [PDF]
Biostatistics, 2019 SUMMARY When the primary outcome is difficult to collect, a surrogate endpoint is typically used as a substitute. It is possible that for every individual, the treatment has a positive effect on the surrogate, and the surrogate has a positive effect on the primary outcome, but for some individuals, the treatment has a negative effect on ...
Ma, Linquan +3 more
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm +11 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook +6 more
wiley +1 more source