Results 31 to 40 of about 813,266 (291)

Generalized Linear Models with Covariate Measurement Error and Zero-Inflated Surrogates

Mathematics
Epidemiological studies often encounter a challenge due to exposure measurement error when estimating an exposure–disease association. A surrogate variable may be available for the true unobserved exposure variable.
Ching-Yun Wang, Jean de Dieu Tapsoba, Catherine Duggan, Anne McTiernan   +3 more
doaj   +1 more source

Surrogate endpoints for overall survival in randomized clinical trials testing immune checkpoint inhibitors: a systematic review and meta-analysis

Frontiers in Immunology
IntroductionThere is debate on which are the best surrogate endpoint and metric to capture treatment effect on overall survival (OS) in RCTs testing immune-checkpoint inhibitors (ICIs).MethodsWe systematically searched for RCTs testing ICIs in patients ...
Isabella Sala, Isabella Sala, Eleonora Pagan, Laura Pala, Chiara Oriecuia, Chiara Oriecuia, Marco Musca, Marco Musca, Claudia Specchia, Tommaso De Pas, Javier Cortes, Javier Cortes, Javier Cortes, Giuseppe Giaccone, Michael Postow, Richard D. Gelber, Vincenzo Bagnardi, Fabio Conforti, Fabio Conforti   +18 more
doaj   +1 more source

Neuroprotective effect of remote ischemic preconditioning in patients undergoing cardiac surgery: A randomized controlled trial

Frontiers in Cardiovascular Medicine, 2022
BackgroundThe neuroprotective effect of remote ischemic preconditioning (RIPC) in patients undergoing elective cardiopulmonary bypass (CPB)-assisted coronary artery bypass graft (CABG) or valvular cardiac surgery remains unclear.MethodsA randomized ...
Shouqiang Zhu, Ziyu Zheng, Wenying Lv, Pengrong Ouyang, Jiange Han, Jiaqiang Zhang, Hailong Dong, Chong Lei   +7 more
doaj   +1 more source

Influence of diesel surrogates on the behavior of simplified spray models [PDF]

, 2012
Numerous experimental investigations make use of diesel surrogates to make the computational time reasonable. In the few studies where measured (surrogate and real diesel) and computed (surrogate only) results have been compared, the selection ...
F Battin-Leclerc, H Wanga, JM Desantes, JV Pastor, N Peters, R Payri, RH Natelson   +6 more
core   +2 more sources

Evaluating Hemagglutination Inhibition Antibody Titers as a Correlate of Protection for Influenza: A Sensitivity Analysis Based on Information Theory and Causal Inference

Journal of Global Infectious Diseases
Introduction: Identifying hemagglutination inhibition (HI) antibody titers as a key immune correlate of protection (CoP) is crucial for developing, licensing, and monitoring the ongoing effectiveness of new influenza vaccines.
Fenny Ong, Geert Molenberghs, Andrea Callegaro, Wim Van Der Elst, Geert Verbeke, Florian Stijven, Ingrid Van Keilegom, Ariel Alonso Abad   +7 more
doaj   +1 more source

Biomarkers, Putative Surrogates, Surrogates, and Decision Making [PDF]

Circulation: Cardiovascular Imaging, 2013
The development of new therapies is slow, expensive, and frustrating. The failure rate for new molecular entities exceeds 90%, and total research and development costs per successful new molecular entity are currently estimated to be nearly $2 billion.1 Consternation about the complexity of therapeutic development recently prompted a major report by ...
openaire   +2 more sources

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

On Machine-Learning-Driven Surrogates for Sound Transmission Loss Simulations

Applied Sciences, 2022
Surrogate models are data-based approximations of computationally expensive simulations that enable efficient exploration of the model’s design space and informed decision making in many physical domains.
Barbara Zaparoli Cunha, Abdel-Malek Zine, Mohamed Ichchou, Christophe Droz, Stéphane Foulard   +4 more
doaj   +1 more source

Pediatric Oncology Nursing Competencies in Latin America and the Caribbean: A Scoping Review to Inform Practice, Education, and Research

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Nurses are central to cancer care for children and adolescents, yet no comprehensive synthesis has defined essential core competencies for pediatric oncology nursing (PON) practice internationally, particularly in Latin America and the Caribbean (LAC).
Luís Carlos Lopes‐Júnior, Edmara Bazoni Soares Maia, Soad Fuentes‐Alabí, Courtney E. Sullivan, Monnie Abraham, Mauricio Maza, Liliana Vásquez Ponce, Regina Aparecida Garcia Lima   +7 more
wiley   +1 more source

A dynamical model of surrogate reactions

, 2010
A new dynamical model is developed to describe the whole process of surrogate reactions; transfer of several nucleons at an initial stage, thermal equilibration of residues leading to washing out of shell effects and decay of populated compound nuclei ...
A. N. Ignatyuk, B. E. J. Pagel, D. Arnett, H. C. Britt, J. D. Cramer, K. Nishio, N. Carjan, P. Fröbrich, R. Bass, S. Chiba, T. Asano, W. U. Schröder, Y. Aritomo   +12 more
core   +1 more source