Results 91 to 100 of about 11,997,994 (262)

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

On Constraint Handling in Surrogate-Assisted Evolutionary Many-Objective Optimization

, 2016
Surrogate-assisted evolutionary multiobjective optimization algorithms are often used to solve computationally expensive problems. But their efficacy on handling constrained optimization problems having more than three objectives has not been widely ...
Sindhya, Karthik, Chugh, Tinkle, Yaochu Jin, Miettinen, Kaisa, Jin, Yaochu, Hakanen, Jussi, Karthik Sindhya, Kaisa Miettinen, Jussi Hakanen, Tinkle Chugh   +9 more
core   +1 more source

Static Formation Temperature Inversion in Ultra-Deep Wells Based on an IGWO-RBF Surrogate Model

Applied Sciences
In ultra-deep well drilling, directly measuring the static formation temperature (SFT) is highly time-consuming, as it requires extended shut-in periods for the wellbore to reach full thermal equilibrium, making it impractical for routine engineering ...
Wenming Li, Feng Lu, Xu Du, Jianfei Xu, Dali Zhang, Wenjie Jia, Zhengming Xu   +6 more
doaj   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source

Aerostructural Optimization of a Composite Low Reynolds Wing Using Surrogate Modeling Techniques

Drones
This study presents an aerostructural optimization framework for the preliminary design of a low-Reynolds-number composite UAV wing, aiming to simultaneously enhance aerodynamic efficiency and structural performance.
Eleftherios Nikolaou, Spyridon Kilimtzidis, Panagiota Kelverkloglou, Vaios Lappas, Vassilis Kostopoulos   +4 more
doaj   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

A framework for surrogate-based aerodynamic optimization [PDF]

, 2011
At DLR, an optimization framework combining different CFD solvers, Design of Experiment methods, optimization algorithms, and various surrogate modeling methodologies with sample refinement strategies for efficient surrogate-based global optimization is ...
Görtz, Stefan, Li, Chunna, Brezillon, Joël   +2 more
core  

Parameter optimization of composite foundation based on BPNN surrogate model and PSO algorithm

四川大学学报. 自然科学版
This paper addresses the low efficiency problem of traditional geotechnical finite element calculation methods used in parameter design and optimization process of composite foundation， which is inherently nonlinear and with multiple constraints.A new ...
YANG Yan, ZHANG Hongling, CHEN Luoping, MA Shuxia   +3 more
doaj  

Investigation of Complement Activation and Cytokine Signatures in AQP4+ NMOSD, MOGAD, and MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Aquaporin‐4‐IgG seropositive neuromyelitis optica spectrum disorder (AQP4+ NMOSD), myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), and multiple sclerosis (MS) are pathophysiologically distinct neuroinflammatory disorders. Complement activation is a major mechanism of injury in AQP4+ NMOSD, whereas its role in
Angeliki G. Filippatou, Susana Dominguez‐Penuela, David Acero‐Garces, Georgios Gakis, Matthew D. Smith, Yasmin Resto, Maria Reyes‐Mantilla, Haiwen Chen, Isabella Hernandez, Yana Said, Andrea Salazar‐Camelo, Christina Huynh, Alessia Tassoni, Ted Yednock, Rick Artis, Yaisa Andrews‐Zwilling, Scott D. Newsome, Shiv Saidha, Pavan Bhargava, Ellen M. Mowry, Kathryn C. Fitzgerald, Peter A. Calabresi, Carlos A. Pardo, Elias S. Sotirchos   +23 more
wiley   +1 more source

Parkinson Disease Subtype Stability and Eventual Convergence

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Previous research identified distinct Parkinson disease (PD) clinical subtypes of “Motor Only,” “Psychiatric & Motor,” and “Cognitive & Motor” based on comprehensive, multidomain classification. Whether these subtypes reflect distinct trajectories or progressive disease stages remains unknown.
Laura M. Rosok, Christina N. Lessov‐Schlaggar, Abdulmunaim M. Eid, Erin R. Foster, Baijayanta Maiti, Hailee Domash, Helen Hwang, Richard J. Perrin, Paul T. Kotzbauer, Joel S. Perlmutter, Meghan C. Campbell   +10 more
wiley   +1 more source