Results 31 to 40 of about 11,997,994 (262)
Convergent surrogate-constraint dynamic programming. [PDF]
, 2006 Wang Qing.Thesis (M.Phil.)--Chinese University of Hong Kong, 2006.Includes bibliographical references (leaves 72-74).Abstracts in English and Chinese.Chapter 1 --- Introduction --- p.1Chapter 1.1 --- Literature survey --- p.2Chapter 1.2 --- Research ...
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Domain knowledge-driven decomposition-based large-scale optimization for ship cabin structures
Zhongguo Jianchuan YanjiuObjectivesThis paper proposes a domain knowledge-driven large-scale optimization algorithm for ship cabin structures based on a decomposition optimization framework.
Puyu JIANG +3 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2021 Virtual and augmented reality offer comparative performance in terms of remote usability testing to lab-based co-located settings. However, direct contact with a researcher is still required to provide setup, troubleshoot, and training. In this paper, we
Andrew Irlitti (15472100) +2 more
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Crashworthiness Optimization Method of Ship Structure under Multi-Working Conditions
Journal of Marine Science and Engineering, 2023 Numerous collision conditions can occur during ship operations, resulting in various consequences that require specific consideration for optimizing crashworthiness design.
Weijian Qiu +5 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Applied Sciences, 2018 Probabilistic constrained simulation optimization problems (PCSOP) are concerned with allocating limited resources to achieve a stochastic objective function subject to a probabilistic inequality constraint.
Shih-Cheng Horng, Shieh-Shing Lin
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source