Results 41 to 50 of about 11,997,994 (262)

A metamodel-based multicriteria shape optimization process for an aerosol can

Alexandria Engineering Journal, 2018
In this paper, we study a multicriteria shape design of a highly nonlinear mechanical 2D structure, namely the shape optimization of the aerosol can bottom.
Aalae Benki, Abderrahmane Habbal, Gael Mathis   +2 more
doaj   +1 more source

First-spike coding promotes accurate and efficient spiking neural networks for discrete events with rich temporal structures

Frontiers in Neuroscience, 2023
Spiking neural networks (SNNs) are well-suited to process asynchronous event-based data. Most of the existing SNNs use rate-coding schemes that focus on firing rate (FR), and so they generally ignore the spike timing in events.
Siying Liu, Vincent C. H. Leung, Pier Luigi Dragotti   +2 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

A constraint qualification characterizing surrogate duality for quasiconvex programming

, 2016
In this paper, we study a constraint qualification which completely characterizes surrogate duality for quasiconvex programming. We show that the closed cone constraint qualification for surrogate duality is a necessary and sufficient constraint ...
Kuroiwa, Daishi, Suzuki, Satoshi
core   +1 more source

Surrogate-based optimization method with adaptive sampling

, 2018
In a typical engineering design workflow, optimization is a highly iterative process, requiring several evaluations of the performance of the item that is being designed. The main goal of the design workflow is to create a cost-effective solution that is
Aldo Rona (7583084), Hakim Kadhim (7804193)   +1 more
core   +3 more sources

A Spectral Approximate Strategy for Energy Management of Hybrid AC/DC System With Uncertainty

IEEE Access, 2020
High proportion of renewable energy and AC-DC hybrid structure are the challenges that the power system has faced. In order to cope with the high-dimensional uncertainties in the hybrid AC/DC system, this work developed a novel method of combining the ...
Jing Li, Wei Wei, Yonggang Peng, Yanjun Li, Duo Xiao   +4 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Lightweight Design of the Baffle Structure in a High-Speed-Train Water Tank Based on an Improved Multi-Objective Particle Swarm Optimization Algorithm

Machines
Lightweight design of high-speed-train water tanks can easily lower the natural frequency of baffles, increasing the risk of resonance and fatigue failure and thus threatening operational safety.
Sihui Dong, Yuebiao Zhao, Xingyu Zhou, Wenhao Bai   +3 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source