Results 41 to 50 of about 64,315 (262)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Domain knowledge-driven decomposition-based large-scale optimization for ship cabin structures
Zhongguo Jianchuan YanjiuObjectivesThis paper proposes a domain knowledge-driven large-scale optimization algorithm for ship cabin structures based on a decomposition optimization framework.
Puyu JIANG +3 more
doaj +1 more source
A metamodel-based multicriteria shape optimization process for an aerosol can
Alexandria Engineering Journal, 2018 In this paper, we study a multicriteria shape design of a highly nonlinear mechanical 2D structure, namely the shape optimization of the aerosol can bottom.
Aalae Benki +2 more
doaj +1 more source
Dimensional Variation Analysis for Rigid Part Assembly With an Improvement of Monte Carlo Simulation
IEEE Access, 2020 Dimensional variation has significant effect on the quality of product. Recently, Monte Carlo (MC) simulation is widely used in dimensional variation analysis, with high accuracy and adaptability, but there is the problem of low computational efficiency.
Wenbin Tang +2 more
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Infrared Small Target Detection via Non-Convex Tensor Rank Surrogate Joint Local Contrast Energy
Remote Sensing, 2020 Small target detection is a crucial technique that restricts the performance of many infrared imaging systems. In this paper, a novel detection model of infrared small target via non-convex tensor rank surrogate joint local contrast energy (NTRS) is ...
Xuewei Guan +3 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
IEEE Access, 2019 Composite ultra-thin boom can be folded elastically. Moreover, such booms are able to self-deploy by releasing stored strain energy, which can be applied in deployable antenna, solar sail, and optical telescopes.
Hui Yang +3 more
doaj +1 more source
Data-informed deep optimization.
PLoS ONE, 2022 Motivated by the impressive success of deep learning in a wide range of scientific and industrial applications, we explore in this work the application of deep learning into a specific class of optimization problems lacking explicit formulas for both ...
Lulu Zhang, Zhi-Qin John Xu, Yaoyu Zhang
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source