Results 51 to 60 of about 145,000 (257)

Assessing surrogate heterogeneity in real world data using meta-learners

Journal of Causal Inference
Surrogate markers are most commonly studied within the context of randomized clinical trials. However, the need for alternative outcomes also extends to real-world public health and social science research, where randomized trials are often impractical ...
Knowlton Rebecca, Parast Layla
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Cardiovascular surrogate markers and cardiometabolic therapeutics: a viewpoint learned from clinical trials on dipeptidyl peptidase-4 inhibitors

Cardiovascular Diabetology, 2021
Clinical trials are often performed to investigate the effects of various types of cardiometabolic therapies on cardiovascular surrogate markers, including vascular function and biomarkers.
Atsushi Tanaka, Koichi Node
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Comparison of the predictive value of different non-insulin-based insulin resistance indices for acute kidney injury in patients with sepsis: a retrospective study

Frontiers in Endocrinology
ObjectiveInsulin resistance (IR) is closely related to the development of acute kidney injury (AKI), but the preferred surrogate markers of IR have not been validated in patients with sepsis.
Shijie Wang, Ruowen Li, Li Zhang, Jiaqi Wang, Tingbin Xie, Xinying Wang   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Surrogate Markers of Cardiorespiratory Fitness for Performance and Health: A Narrative Review

Applied Sciences
Cardiorespiratory fitness (CRF) is both an indicator of athletic performance and disease and mortality risk. The gold standard for measuring CRF is a VO2peak test, which is inaccessible to the general population and non-elite athletes.
Joshua J. Aube, Lucas P. R. Beaupre, Brendon J. Gurd   +2 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A critical review of diagnostic and prognostic markers of chronic hepatitis B infection

Medical Review
A major worldwide health concern, chronic hepatitis B necessitates precise prognostic and diagnostic indicators for clinical guidance. This article highlights the clinical importance and current issues of the major markers used in both the detection and ...
Hudu Shuaibu Abdullahi, Shinkafi Sa’adatu Haruna, Jimoh Abdulgafar Olayiwola   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source