Results 201 to 210 of about 14,186,820 (252)

Lightweight design of excavator working device based on automatically generated surrogate model. [PDF]

Sci Rep
Zhang H, Ge XB, Li Y, Shao XD, Jia MM.
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model. [PDF]

CPT Pharmacometrics Syst Pharmacol
Iwata H, Saito R.
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Improving Nanoparticle Size Estimation from Scanning Transmission Electron Micrographs with a Multislice Surrogate Model. [PDF]

Nano Lett
Eliasson H, Erni R.
europepmc   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Active learning for adaptive surrogate model improvement in high-dimensional problems. [PDF]

Struct Multidiscipl Optim
Guo Y, Nath P, Mahadevan S, Witherell P.
europepmc   +1 more source

Evaluating an epidemiologically motivated surrogate model of a multi-model ensemble

, 2022
Abbott S, Sherratt K, Bosse N, Gruson H, Bracher J, Funk S.   +5 more
europepmc   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

An Optimal Design Method for Lightweight Heating Film of Anisotropic Heat Conduction Substrate Based on Surrogate Model. [PDF]

Micromachines (Basel)
Deng Z, Yu Q, Liu J, Wang Y, Yan S, Huai N, Zhang J, Gao H.   +7 more
europepmc   +1 more source