Using machine learning as a surrogate model for agent-based simulations. [PDF]
PLoS One, 2022 Angione C, Silverman E, Yaneske E.
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Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
A pathology-based surrogate model for chemotherapy decision-making in intermediate-risk luminal breast cancer: validation of histologic grade and Ki67 in a Chinese population. [PDF]
Front Med (Lausanne)Li G, Zeng Y, Sun Y.
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Comparison of parallel infill sampling criteria based on Kriging surrogate model. [PDF]
Sci Rep, 2022 Chen C, Liu J, Xu P.
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Multi-marker discovery for mild cognitive impairment in metabolomics using machine learning with a global surrogate model via partial least squares. [PDF]
MetabolomicsTatara Y +8 more
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The Monocytic Cell Line THP-1 as a Validated and Robust Surrogate Model for Human Dendritic Cells. [PDF]
Int J Mol Sci, 2023 Hölken JM, Teusch N.
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FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
Speed up Multi-Scale Force-Field Parameter Optimization by Substituting Molecular Dynamics Calculations with a Machine Learning Surrogate Model. [PDF]
ChemphyschemStrickstrock R +3 more
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DeepSCM: An efficient convolutional neural network surrogate model for the screening of therapeutic antibody viscosity. [PDF]
Comput Struct Biotechnol J, 2022 Lai PK.
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