Results 221 to 230 of about 22,296,575 (338)

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Improving Nanoparticle Size Estimation from Scanning Transmission Electron Micrographs with a Multislice Surrogate Model. [PDF]

Nano Lett
Eliasson H, Erni R.
europepmc   +1 more source

Machine Learning-Based Surrogate Model for Press Hardening Process of 22MnB5 Sheet Steel Simulation in Industry 4.0. [PDF]

Materials (Basel), 2022
Abio A, Bonada F, Pujante J, Grané M, Nievas N, Lange D, Pujol O.   +6 more
europepmc   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Active learning for adaptive surrogate model improvement in high-dimensional problems. [PDF]

Struct Multidiscipl Optim
Guo Y, Nath P, Mahadevan S, Witherell P.
europepmc   +1 more source

Evaluating an epidemiologically motivated surrogate model of a multi-model ensemble

, 2022
Abbott S, Sherratt K, Bosse N, Gruson H, Bracher J, Funk S.   +5 more
europepmc   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

An Optimal Design Method for Lightweight Heating Film of Anisotropic Heat Conduction Substrate Based on Surrogate Model. [PDF]

Micromachines (Basel)
Deng Z, Yu Q, Liu J, Wang Y, Yan S, Huai N, Zhang J, Gao H.   +7 more
europepmc   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Design optimization of large-scale bifacial photovoltaic module frame using deep learning surrogate model. [PDF]

Sci Rep
Han D, Kim S.
europepmc   +1 more source