Results 51 to 60 of about 14,186,820 (252)

Using machine learning surrogate modeling for faster QSP VP cohort generation

CPT: Pharmacometrics & Systems Pharmacology, 2023
Virtual patients (VPs) are widely used within quantitative systems pharmacology (QSP) modeling to explore the impact of variability and uncertainty on clinical responses.
Renée C. Myers, Florian Augustin, Jérémy Huard, Christina M. Friedrich   +3 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

A Surrogate Model Based on Artificial Neural Networks for Wave Propagation in Uncertain Media

IEEE Access, 2020
Soil materials can exhibit strongly dispersive properties in the operating frequency range of a physical system, and the uncertain parameters of the dispersive materials introduce uncertainties in the simulation result of propagating waves.
Xi Cheng, Zhi-Yong Zhang, Wei Shao
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

AI-Driven Surrogate Model for Room Ventilation

Fluids
The control of ventilation systems is often performed by automatic algorithms which often do not consider the future evolution of the system in its control politics. Digital twins allow system forecasting for a more sophisticated control.
Jaume Luis-Gómez, Francisco Martínez, Alejandro González-Barberá, Javier Mascarós, Guillem Monrós-Andreu, Sergio Chiva, Elisa Borrás, Raúl Martínez-Cuenca   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Quantifying the improvement of surrogate indices of hepatic insulin resistance using complex measurement techniques [PDF]

, 2012
We evaluated the ability of simple and complex surrogate-indices to identify individuals from an overweight/obese cohort with hepatic insulin-resistance (HEP-IR).
Martin Osterhoff, Osterhoff Martin, Pfeiffer, Andreas F. H., Christian V Loeffelholz, Roden, Michael, Dr., Loeffelholz Christian v., Pfeiffer Andreas F. H., Nowotny, Peter, Möhlig Matthias, Nowotny Peter, Khan, Michael, Hattersley, John G., Weickert Martin O., Hierholzer, Johannes, Martin O Weickert, Arafat Ayman M., Roden Michael, Arafat, Ayman M., Machann Jürgen, Peter Nowotny, Weickert, Martin O., Möhlig, Matthias, Loeffelholz, Christian von, Hattersley John G., Michael Khan, Johannes Hierholzer, John G Hattersley, Matthias Möhlig, Michael Roden, Osterhoff, Martin, Khan Michael, Andreas F H Pfeiffer, Ayman M Arafat, Hierholzer Johannes, Jürgen Machann, Machann, Jürgen   +35 more
core   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source