Results 71 to 80 of about 14,186,820 (252)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Active learning based surrogate ensemble assisted multi-objective optimization framework for reservoir water-flooding optimization

Journal of Petroleum Exploration and Production Technology
Surrogate-assisted management of water-flooding, as a reservoir production optimization strategy, dynamically adjusts development schemes at each production step, leading to improved economic benefits and enhanced recovery.
Lian Wang, Liang Zhang, Rui Deng, Jianhua Qu, Hehua Wang, Liehui Zhang, Xing Zhao, Bing Xu, Xindong Lv, Caspar Daniel Adenutsi   +9 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Simulation of the Oxidation and Combustion of Mixed Diesel-Biodiesel Fuel

MATEC Web of Conferences, 2018
A comparative simulation-based research has been set up to obtain valid kinetic models of the oxidation and combustion of biodiesel surrogate and diesel surrogate, as well as mixed diesel-biodiesel surrogates which is used to predict their ignition delay
Muharam Yuswan, Leonardi Danny, Ramadhania Alisya P   +2 more
doaj   +1 more source

Surrogate Model Assisted Design of CSRR Structure using Genetic Algorithm for Microstrip Antenna Application [PDF]

Radioengineering, 2020
Soft-computational approaches have enabled quicker and more efficient means for antenna design. In the present work, a genetic algorithm (GA) based method is reported for the design of complementary split ring resonator (CSRR) structures for antenna ...
K. Sarmah, S. Goswami, S. Baruah
doaj  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Surrogate modeling approximation using a mixture of experts based on EM joint estimation [PDF]

, 2010
An automatic method to combine several local surrogate models is presented. This method is intended to build accurate and smooth approximation of discontinuous functions that are to be used in structural optimization problems.
Dimitri Bettebghor, Joseph Morlier, Samuelides, Manuel, Morlier, Joseph, Nathalie Bartoli, Bettebghor, Dimitri, Grihon, Stéphane, Manuel Samuelides, Bartoli, Nathalie, Stéphane Grihon   +9 more
core   +1 more source

Study on the Surrogate Model of Groundwater Numerical Simulation Model Based on Radial Basis Function Neural Network

Shuitu baochi yanjiu, 2012
In recent years,the surrogate model has become an effective way to connect the numerical simulation model and optimization model.The quality of surrogate model depends on sampling method and the type of surrogate model.In this paper,Jinquan Industrial ...
YI Yan-ping1, LU Wen-xi2, ZHANG Yun1, LU Gui-jun3, WANG Da-zhong3, HONG De-fa4   +5 more
doaj  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source