Results 71 to 80 of about 561,088 (291)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
IEEE AccessExpensive optimization problems are characterized by the significant amount of time and resources needed to determine the quality of potential solutions.
Mario Garza-Fabre +3 more
doaj +1 more source
, 2015 The authors present a Polynomial Chaos (PC)-based Bayesian inference method for quantifying the uncertainties of the K-Profile Parametrization (KPP) within the MIT General Circulation Model (MITgcm) of the tropical pacific. The inference of the uncertain
Hoteit, Ibrahim +4 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
AI-Driven Surrogate Model for Room Ventilation
FluidsThe control of ventilation systems is often performed by automatic algorithms which often do not consider the future evolution of the system in its control politics. Digital twins allow system forecasting for a more sophisticated control.
Jaume Luis-Gómez +7 more
doaj +1 more source
Decomposition-Assisted Computational Technique Based on Surrogate Modeling for Real-Time Simulations
Complexity, 2017 The development of complex simulation systems is extremely costly as it requires high computational capability and expensive hardware. As cost is one of the main issues in developing simulation components, achieving real-time simulation is challenging ...
Nariman Fouladinejad +3 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Online learning supported surrogate-based flowsheet model maintenance
Digital Chemical EngineeringSurrogate-based flowsheet model calibration is a critical extension of using flowsheet models in Digital Twin (DT) systems. However, maintaining accurate surrogates over time is increasingly challenging, especially when models are deployed in real-time ...
Balázs Palotai +3 more
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Surrogate Modeling: Review and Opportunities for Expert Knowledge Integration
Procedia Computer ScienceDigital Twins (DTs), essential for digitalization and Industry 4.0, demand high-fidelity yet computationally efficient models for real-time replication of physical systems. However, simulating continuous dynamical systems, often stiff and highly granular, poses significant computational challenges.
Šturek, Dušan, Lazarova-Molnar, Sanja
openaire +3 more sources