Results 91 to 100 of about 561,088 (291)

An adaptive sampling method for global sensitivity analysis based on least-squares support vector regression [PDF]

, 2018
In the field of engineering, surrogate models are commonly used for approximating the behavior of a physical phenomenon in order to reduce the computational costs.
Bourinet, Jean-Marc, Lahmer, Tom (Prof.), Steiner, Maria (M.Sc.)   +2 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Radiation shielding optimization based on dynamic radial basis surrogate model of particle flight

He jishu
BackgroundRadiation shielding is crucial for ensuring the environmental safety of personnel and nuclear facilities in the nuclear industry. As it usually consumes a long time in single simulation calculation, the optimization design of radiation ...
GAO Shuai, GUAN Xingyin, LU Yi, YE Yang, YUAN Yuan, HAO Shuai, HU Qihang, ZHANG Yong   +7 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A high-fidelity surrogate model for the ion temperature gradient (ITG) instability using a small expensive simulation dataset

Nuclear Fusion
One of the main challenges in building high-fidelity surrogate models of tokamak turbulence is the substantial demand for high-quality data. Typically, producing high-quality data involves simulating complex physical processes, which requires extensive ...
Chenguang Wan, Youngwoo Cho, Zhisong Qu, Yann Camenen, Robin Varennes, Kyungtak Lim, Kunpeng Li, Jiangang Li, Yanlong Li, Xavier Garbet   +9 more
doaj   +1 more source

An Adaptive Surrogate-Assisted Particle Swarm Optimization Algorithm Combining Effectively Global and Local Surrogate Models and Its Application

Applied Sciences
Numerous surrogate-assisted evolutionary algorithms have been proposed for expensive optimization problems. However, each surrogate model has its own characteristics and different applicable situations, which caused a serious challenge for model ...
Shaochun Qu, Fuguang Liu, Zijian Cao
doaj   +1 more source

Continuous-discrete variable optimization on composites using kriging surrogate model [PDF]

, 2011
This work describes a mixed continuous-discrete variable optimization procedure\ud for thermoplastic composite panels. Minimum weight configuration is the goal. Buckling constraint is applied to the problem. A Kriging surrogate model of the constraint is
Boer, André de, De Guido, Samuele, Geijselaers, H.J.M.   +2 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source