Results 81 to 90 of about 14,186,820 (252)
Investigating the use of rubber to attenuate the effect of blast load applied to a surrogate lower leg [PDF]
, 2008 Includes abstract.Includes bibliographical references (leaves 191-197).Landmines are the epitome of the perfect soldier: always ready, never tiring. Landmines also do not choose their victims - it may very well be an armed and protected soldier or an ...
Ungerer, Delmarie
core +1 more source
Radiation shielding optimization based on dynamic radial basis surrogate model of particle flight
He jishuBackgroundRadiation shielding is crucial for ensuring the environmental safety of personnel and nuclear facilities in the nuclear industry. As it usually consumes a long time in single simulation calculation, the optimization design of radiation ...
GAO Shuai +7 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
, 2021 Virtual and augmented reality offer comparative performance in terms of remote usability testing to lab-based co-located settings. However, direct contact with a researcher is still required to provide setup, troubleshoot, and training. In this paper, we
Andrew Irlitti (15472100) +2 more
core
Applied SciencesNumerous surrogate-assisted evolutionary algorithms have been proposed for expensive optimization problems. However, each surrogate model has its own characteristics and different applicable situations, which caused a serious challenge for model ...
Shaochun Qu, Fuguang Liu, Zijian Cao
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Nuclear FusionOne of the main challenges in building high-fidelity surrogate models of tokamak turbulence is the substantial demand for high-quality data. Typically, producing high-quality data involves simulating complex physical processes, which requires extensive ...
Chenguang Wan +9 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source