Results 81 to 90 of about 561,088 (291)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Active learning based surrogate ensemble assisted multi-objective optimization framework for reservoir water-flooding optimization

Journal of Petroleum Exploration and Production Technology
Surrogate-assisted management of water-flooding, as a reservoir production optimization strategy, dynamically adjusts development schemes at each production step, leading to improved economic benefits and enhanced recovery.
Lian Wang, Liang Zhang, Rui Deng, Jianhua Qu, Hehua Wang, Liehui Zhang, Xing Zhao, Bing Xu, Xindong Lv, Caspar Daniel Adenutsi   +9 more
doaj   +1 more source

Determination of Bond Wire Failure Probabilities in Microelectronic Packages

, 2016
This work deals with the computation of industry-relevant bond wire failure probabilities in microelectronic packages. Under operating conditions, a package is subject to Joule heating that can lead to electrothermally induced failures.
Casper, Thorben, Römer, Ulrich, Schöps, Sebastian   +2 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Surrogate Model Assisted Design of CSRR Structure using Genetic Algorithm for Microstrip Antenna Application [PDF]

Radioengineering, 2020
Soft-computational approaches have enabled quicker and more efficient means for antenna design. In the present work, a genetic algorithm (GA) based method is reported for the design of complementary split ring resonator (CSRR) structures for antenna ...
K. Sarmah, S. Goswami, S. Baruah
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Simulation of the Oxidation and Combustion of Mixed Diesel-Biodiesel Fuel

MATEC Web of Conferences, 2018
A comparative simulation-based research has been set up to obtain valid kinetic models of the oxidation and combustion of biodiesel surrogate and diesel surrogate, as well as mixed diesel-biodiesel surrogates which is used to predict their ignition delay
Muharam Yuswan, Leonardi Danny, Ramadhania Alisya P   +2 more
doaj   +1 more source

Rapidly Tuning the PID Controller Based on the Regional Surrogate Model Technique in the UAV Formation

Entropy, 2020
The leader–follower structure is widely used in unmanned aerial vehicle formation. This paper adopts the proportional-integral-derivative (PID) and the linear quadratic regulator controllers to construct the leader–follower formation.
Binglin Wang, Xiaojun Duan, Liang Yan, Juan Deng, Jiangtao Chen   +4 more
doaj   +1 more source

Surrogate Residuals for Discrete Choice Models

Journal of Computational and Graphical Statistics, 2020
Discrete choice models (DCMs) are a class of models for modeling response variables that take values from a set of alternatives. Examples include logistic regression, probit regression, and multinomial logistic regression. These models are also referred together as generalized linear models. Although there exist methods for the goodness of fit of DCMs,
Chao, Cheng, Rui, Wang, Heping, Zhang
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source