Results 261 to 270 of about 24,324,331 (382)

Active Learning Enhanced Surrogate Modeling of Jet Engines in JuliaSim [PDF]

Anas Abdelrehim, Dhairya Gandhi, Sharan Yalburgi, Ashutosh Bharambe, Ranjan Anantharaman, Christopher Rackauckas   +5 more
openalex   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Surrogate modeling of electrospun PVA/PLA nanofibers using artificial neural network for biomedical applications. [PDF]

Sci Rep
Fatahian R, Erfani R.
europepmc   +1 more source

Construction and Validation of a Data-Driven Static Surrogate Model for Prestressed Steel-Concrete Joints [PDF]

Li Chong, Yu Fangliang, Zheng Luyao, Li Bo   +3 more
openalex   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

An Assessment of Local Geometric Uncertainties in Polysilicon MEMS: A Genetic Algorithm and POD-Kriging Surrogate Modeling Approach. [PDF]

Micromachines (Basel)
Roy A, Rizzini F, Gattere G, Valzasina C, Ghisi A, Mariani S.   +5 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Comparison of Hybrid Machine Learning Approaches for Surrogate Modeling Part Shrinkage in Injection Molding. [PDF]

Polymers (Basel)
Wenzel M, Raisch SR, Schmitz M, Hopmann C.   +3 more
europepmc   +1 more source

Surrogate Modeling of Methane Yield in Anaerobic Digestion under Heterogeneous Feedstock Conditions

К. Witaszek, Nikolay Kiktev, Vololdymyr Reshetiuk, Tomasz Garbowski   +3 more
openalex   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source