Results 41 to 50 of about 186,324 (294)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Transfusion‐related iron overload (TRIO) is a late effect of therapy impacting survivors of childhood cancer and hematopoietic stem cell transplantation (HSCT) who receive frequent packed red blood cell (pRBC) transfusions. Surprisingly, there are no accepted guidelines to assist providers in identifying and treating at‐risk ...
Luke Gingell +3 more
wiley +1 more source
MYCN Amplification in RB1‐Inactivated Retinoblastoma: Association With High‐Risk Features
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background MYCN amplification occurs in a subset of retinoblastoma cases, both with and without RB1 inactivation. It has been suggested that retinoblastomas with MYCN amplification represent a distinct entity with more aggressive clinical behavior.
Kyriaki Papaioannou +9 more
wiley +1 more source
Implementation of Surrogate Models for the Analysis of Slope Problems
Geosciences, 2023 Numerical modeling is increasingly used to analyze practical rock engineering problems. The geological strength index (GSI) is a critical input for many rock engineering problems.
Amichai Mitelman +2 more
doaj +1 more source
Active learning for feasible region discovery [PDF]
, 2019 Often in the design process of an engineer, the design specifications of the system are not completely known initially. However, usually there are some physical constraints which are already known, corresponding to a region of interest in the design ...
Couckuyt, Ivo +3 more
core +1 more source
Kernel Methods for Surrogate Modeling
, 2019 This chapter deals with kernel methods as a special class of techniques for surrogate modeling. Kernel methods have proven to be efficient in machine learning, pattern recognition and signal analysis due to their flexibility, excellent experimental performance and elegant functional analytic background.
Santin G., Haasdonk B.
openaire +2 more sources
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
IEEE AccessThis paper presents a novel surrogate modeling approach for estimating the dynamic radar cross-section (RCS) of chaff clouds under diverse launch and environmental conditions.
Jun-Seon Kim +6 more
doaj +1 more source
Predictive haemodynamics in a one-dimensional human carotid artery bifurcation. Part II: application to graft design [PDF]
, 2008 A Bayesian surrogate modelling technique is proposed that may be able to predict an optimal bypass graft configuration for patients suffering with stenosis in the internal carotid artery (ICA). At the outset, this statistical technique is considered as a
Bressloff, N. W. +3 more
core +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source